Stem Cells in the Eye

Mike Boulton, Julie Albon, Maria B. Grant

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Spinal cord injury is a major medical problem because there currently is no way to repair the central nervous system and restore function. In this chapter, we focus on embryonic stem cells as an important research tool and potential therapy. We quickly review the epidemiology, functional anatomy, and pathophysiology of spinal cord injury and then discuss spontaneous regeneration and current limitations on repair. We also summarize features of spinal cord development that might guide restoration strategies. We then review studies that have utilized embryonic stem cells in spinal cord repair. We conclude that progress has been good, that knowledge is still too limited, and that harnessing the potential of embryonic stem cells will be important for solving the problem of spinal cord injury.

Original languageEnglish (US)
Title of host publicationPrinciples of Tissue Engineering
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Pages1399-1412
Number of pages14
ISBN (Print)9780123983589
DOIs
StatePublished - Nov 1 2013

Keywords

  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Spinal cord injury
  • Spontaneous regeneration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Boulton, M., Albon, J., & Grant, M. B. (2013). Stem Cells in the Eye. In Principles of Tissue Engineering: Fourth Edition (pp. 1399-1412). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398358-9.00066-5