Stem Cells in the Eye

Mike Boulton, Julie Albon, Maria B. Grant

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Spinal cord injury is a major medical problem because there currently is no way to repair the central nervous system and restore function. In this chapter, we focus on embryonic stem cells as an important research tool and potential therapy. We quickly review the epidemiology, functional anatomy, and pathophysiology of spinal cord injury and then discuss spontaneous regeneration and current limitations on repair. We also summarize features of spinal cord development that might guide restoration strategies. We then review studies that have utilized embryonic stem cells in spinal cord repair. We conclude that progress has been good, that knowledge is still too limited, and that harnessing the potential of embryonic stem cells will be important for solving the problem of spinal cord injury.

Original languageEnglish
Title of host publicationPrinciples of Tissue Engineering: Fourth Edition
PublisherElsevier Inc.
Pages1399-1412
Number of pages14
ISBN (Print)9780123983589
DOIs
StatePublished - Nov 2013

Fingerprint

Embryonic Stem Cells
Stem cells
Spinal Cord Injuries
Stem Cells
Spinal Cord Regeneration
Repair
Regeneration
Spinal Cord
Anatomy
Epidemiology
Central Nervous System
Neurology
Medical problems
Restoration
Research
Therapeutics

Keywords

  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Spinal cord injury
  • Spontaneous regeneration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Boulton, M., Albon, J., & Grant, M. B. (2013). Stem Cells in the Eye. In Principles of Tissue Engineering: Fourth Edition (pp. 1399-1412). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398358-9.00066-5

Stem Cells in the Eye. / Boulton, Mike; Albon, Julie; Grant, Maria B.

Principles of Tissue Engineering: Fourth Edition. Elsevier Inc., 2013. p. 1399-1412.

Research output: Chapter in Book/Report/Conference proceedingChapter

Boulton, M, Albon, J & Grant, MB 2013, Stem Cells in the Eye. in Principles of Tissue Engineering: Fourth Edition. Elsevier Inc., pp. 1399-1412. https://doi.org/10.1016/B978-0-12-398358-9.00066-5
Boulton M, Albon J, Grant MB. Stem Cells in the Eye. In Principles of Tissue Engineering: Fourth Edition. Elsevier Inc. 2013. p. 1399-1412 https://doi.org/10.1016/B978-0-12-398358-9.00066-5
Boulton, Mike ; Albon, Julie ; Grant, Maria B. / Stem Cells in the Eye. Principles of Tissue Engineering: Fourth Edition. Elsevier Inc., 2013. pp. 1399-1412
@inbook{e698e2957f0043918c6c26122e1d6fa8,
title = "Stem Cells in the Eye",
abstract = "Spinal cord injury is a major medical problem because there currently is no way to repair the central nervous system and restore function. In this chapter, we focus on embryonic stem cells as an important research tool and potential therapy. We quickly review the epidemiology, functional anatomy, and pathophysiology of spinal cord injury and then discuss spontaneous regeneration and current limitations on repair. We also summarize features of spinal cord development that might guide restoration strategies. We then review studies that have utilized embryonic stem cells in spinal cord repair. We conclude that progress has been good, that knowledge is still too limited, and that harnessing the potential of embryonic stem cells will be important for solving the problem of spinal cord injury.",
keywords = "Embryonic stem cells, Induced pluripotent stem cells, Spinal cord injury, Spontaneous regeneration",
author = "Mike Boulton and Julie Albon and Grant, {Maria B.}",
year = "2013",
month = "11",
doi = "10.1016/B978-0-12-398358-9.00066-5",
language = "English",
isbn = "9780123983589",
pages = "1399--1412",
booktitle = "Principles of Tissue Engineering: Fourth Edition",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Stem Cells in the Eye

AU - Boulton, Mike

AU - Albon, Julie

AU - Grant, Maria B.

PY - 2013/11

Y1 - 2013/11

N2 - Spinal cord injury is a major medical problem because there currently is no way to repair the central nervous system and restore function. In this chapter, we focus on embryonic stem cells as an important research tool and potential therapy. We quickly review the epidemiology, functional anatomy, and pathophysiology of spinal cord injury and then discuss spontaneous regeneration and current limitations on repair. We also summarize features of spinal cord development that might guide restoration strategies. We then review studies that have utilized embryonic stem cells in spinal cord repair. We conclude that progress has been good, that knowledge is still too limited, and that harnessing the potential of embryonic stem cells will be important for solving the problem of spinal cord injury.

AB - Spinal cord injury is a major medical problem because there currently is no way to repair the central nervous system and restore function. In this chapter, we focus on embryonic stem cells as an important research tool and potential therapy. We quickly review the epidemiology, functional anatomy, and pathophysiology of spinal cord injury and then discuss spontaneous regeneration and current limitations on repair. We also summarize features of spinal cord development that might guide restoration strategies. We then review studies that have utilized embryonic stem cells in spinal cord repair. We conclude that progress has been good, that knowledge is still too limited, and that harnessing the potential of embryonic stem cells will be important for solving the problem of spinal cord injury.

KW - Embryonic stem cells

KW - Induced pluripotent stem cells

KW - Spinal cord injury

KW - Spontaneous regeneration

UR - http://www.scopus.com/inward/record.url?scp=84903222460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903222460&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-398358-9.00066-5

DO - 10.1016/B978-0-12-398358-9.00066-5

M3 - Chapter

AN - SCOPUS:84903222460

SN - 9780123983589

SP - 1399

EP - 1412

BT - Principles of Tissue Engineering: Fourth Edition

PB - Elsevier Inc.

ER -