Stent-based approach for ventricle-to-coronary artery bypass

Peter Boekstegers, Philip Raake, Rasul Al Ghobainy, Jan Horstkotte, Rabea Hinkel, Torleif Sandner, Reinhard Wichels, Franz Meisner, Eckehard Thein, Keith March, Dieter Boehm, Hermann Reichenspurner

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27 Scopus citations

Abstract

Background - Ventricle-to-coronary artery bypass (VCAB) is an experimental revascularization procedure that provides predominantly systolic instead of diastolic blood flow to a coronary artery. Methods and Results - In a pig model, a stent-based procedure (VSTENT) was developed to create a VCAB. After thoracotomy, a covered VSTENT was implanted between the left ventricle and the left anterior descending coronary artery (LAD). Distal LAD flow, regional myocardial function, and intracoronary pressures were determined at different degrees of LAD stenosis and during complete LAD occlusion. During 3 hours of LAD occlusion, VSTENT preserved net forward flow at 70±6% and regional myocardial function at 71±8% of baseline. Preservation of net flow was influenced by the positioning of the VSTENT, with higher preservation also under conditions of increased oxygen demand if a "valve-like mechanism" was present during diastole. At a hemodynamically relevant level of LAD stenosis (>70%), systolic inflow was predominant after VSTENT implantation. Changes in mean diastolic intracoronary pressure that resulted from different degrees of LAD stenosis were linearly correlated to net flow after VSTENT implantation (r=0.88; P<0.001). Conclusions - VSTENT for ventricle-to-coronary artery bypass was feasible and preserved 70±6% of baseline flow during complete LAD occlusion. The degree of preservation was dependent on the position of the VSTENT creating a valve-like mechanism during diastole. Residual diastolic blood flow through a high-grade LAD stenosis influenced net flow favorably, because diastolic backflow decreased with increasing mean diastolic intracoronary pressure.

Original languageEnglish (US)
Pages (from-to)1000-1006
Number of pages7
JournalCirculation
Volume106
Issue number8
DOIs
StatePublished - Aug 20 2002

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Keywords

  • Arteries
  • Revascularization
  • Shunts
  • Stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Boekstegers, P., Raake, P., Al Ghobainy, R., Horstkotte, J., Hinkel, R., Sandner, T., Wichels, R., Meisner, F., Thein, E., March, K., Boehm, D., & Reichenspurner, H. (2002). Stent-based approach for ventricle-to-coronary artery bypass. Circulation, 106(8), 1000-1006. https://doi.org/10.1161/01.CIR.0000027106.88111.77