Stent-induced coronary artery stenosis characterized by multimodal nonlinear optical microscopy

Han Wei Wang, Vlad Simianu, Mattew J. Locker, Ji Xin Cheng, Michael Sturek

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We demonstrate for the first time the applicability of multimodal nonlinear optical (NLO) microscopy to the interrogation of stented coronary arteries under different diet and stent deployment conditions. Bare metal stents and Taxus drug-eluting stents (DES) were placed in coronary arteries of Ossabaw pigs of control and atherogenic diet groups. Multimodal NLO imaging was performed to inspect changes in arterial structures and compositions after stenting. Sum frequency generation, one of the multimodalities, was used for the quantitative analysis of collagen content in the peristent and in-stent artery segments of both pig groups. Atherogenic diet increased lipid and collagen in peristent segments. In-stent segments showed decreased collagen expression in neointima compared to media. Deployment of DES in atheromatous arteries inhibited collagen expression in the arterial media.

Original languageEnglish (US)
Article number021110
JournalJournal of Biomedical Optics
Volume16
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • coronary arteries
  • drug eluting stents
  • multimodal nonlinear optical microscopy
  • Ossabaw miniature swine
  • stenosis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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