OBJECTIVE: Recent studies have identified a group of polyps, usually located in the proximal colon, with distinct endoscopic features that predict hyperplastic histology. These polyps may occasionally have foci of dysplastic (adenomatous) tissue. We aimed to define the prevalence of adenomatous foci in these polyps. METHODS: Fifty-one consecutive hyperplastic-appearing proximal colon polyps were sectioned at 1-mm intervals for histological analysis. RESULTS: All 51 polyps were hyperplastic, but two (4%) had foci of adenomatous tissue. CONCLUSION: The prevalence of adenomatous foci in proximal colon polyps with endoscopic features of hyperplastic polyps is low. Whether endoscopic resection of polyps with these features is warranted remains uncertain.
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