Stereotactic core-needle breast biopsy

A multi-institutional prospective trial

R. J. Brenner, L. W. Bassett, L. L. Fajardo, D. D. Dershaw, W. P. Evans, R. Hunt, C. Lee, I. Tocino, P. Fisher, M. McCombs, Valerie Jackson, S. A. Feig, E. B. Mendelson, F. R. Margolin, R. Bird, J. Sayre

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

PURPOSE: To assess the accuracy of stereotactic core-needle biopsy (CNB) of nonpalpable breast lesions within the context of clinically important parameters of anticipated tissue-sampling error and concordance with mammographic findings. MATERIALS AND METHODS: CNB was performed in 1,003 patients, with results validated at surgery or clinical and mammographic follow-up. Mammographic findings were scored according to the American College of Radiology Breast Imaging Reporting and Data System with a similar correlative scale for histopathologic samples obtained at either CNB or surgery. Agreement of CNB findings With surgical findings or evidence of no change during clinical and mammographic follow-up (median, 24 months) for benign lesions was used to determine results. Three forms of diagnostic discrimination measures (strict, working [strict conditioned by tissue sampling error], applied [working conditioned by concordance of imaging and CNB findings) were used to evaluate the correlation of CNB, surgical, and follow-up results. RESULTS: Strict, working, and applied sensitivities were 91% ± 1.9; 92% ± 1.8, and 98% ± 0.9, respectively; strict, working, and applied specificities were 100%, 98% ± 0.8, and 73% ± 0.9; strict, working, and applied accuracies were 97%, 96%, and 79%. CONCLUSION: Percutaneous stereotactic CNB is an accurate method to establish a histopathologic diagnosis of nonpalpable breast lesions. Accuracy increases when additional surgery is performed for lesions with anticipated sampling error or when CNB findings are discordant with mammographic findings. An understanding of the interrelationship among these parameters is necessary to properly assess results.

Original languageEnglish (US)
Pages (from-to)866-872
Number of pages7
JournalRadiology
Volume218
Issue number3
StatePublished - 2001
Externally publishedYes

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Large-Core Needle Biopsy
Breast
Selection Bias
Radiology
Information Systems

Keywords

  • Breast neoplasms, diagnosis
  • Breast radiography, utilization
  • Breast, biopsy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Brenner, R. J., Bassett, L. W., Fajardo, L. L., Dershaw, D. D., Evans, W. P., Hunt, R., ... Sayre, J. (2001). Stereotactic core-needle breast biopsy: A multi-institutional prospective trial. Radiology, 218(3), 866-872.

Stereotactic core-needle breast biopsy : A multi-institutional prospective trial. / Brenner, R. J.; Bassett, L. W.; Fajardo, L. L.; Dershaw, D. D.; Evans, W. P.; Hunt, R.; Lee, C.; Tocino, I.; Fisher, P.; McCombs, M.; Jackson, Valerie; Feig, S. A.; Mendelson, E. B.; Margolin, F. R.; Bird, R.; Sayre, J.

In: Radiology, Vol. 218, No. 3, 2001, p. 866-872.

Research output: Contribution to journalArticle

Brenner, RJ, Bassett, LW, Fajardo, LL, Dershaw, DD, Evans, WP, Hunt, R, Lee, C, Tocino, I, Fisher, P, McCombs, M, Jackson, V, Feig, SA, Mendelson, EB, Margolin, FR, Bird, R & Sayre, J 2001, 'Stereotactic core-needle breast biopsy: A multi-institutional prospective trial', Radiology, vol. 218, no. 3, pp. 866-872.
Brenner RJ, Bassett LW, Fajardo LL, Dershaw DD, Evans WP, Hunt R et al. Stereotactic core-needle breast biopsy: A multi-institutional prospective trial. Radiology. 2001;218(3):866-872.
Brenner, R. J. ; Bassett, L. W. ; Fajardo, L. L. ; Dershaw, D. D. ; Evans, W. P. ; Hunt, R. ; Lee, C. ; Tocino, I. ; Fisher, P. ; McCombs, M. ; Jackson, Valerie ; Feig, S. A. ; Mendelson, E. B. ; Margolin, F. R. ; Bird, R. ; Sayre, J. / Stereotactic core-needle breast biopsy : A multi-institutional prospective trial. In: Radiology. 2001 ; Vol. 218, No. 3. pp. 866-872.
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abstract = "PURPOSE: To assess the accuracy of stereotactic core-needle biopsy (CNB) of nonpalpable breast lesions within the context of clinically important parameters of anticipated tissue-sampling error and concordance with mammographic findings. MATERIALS AND METHODS: CNB was performed in 1,003 patients, with results validated at surgery or clinical and mammographic follow-up. Mammographic findings were scored according to the American College of Radiology Breast Imaging Reporting and Data System with a similar correlative scale for histopathologic samples obtained at either CNB or surgery. Agreement of CNB findings With surgical findings or evidence of no change during clinical and mammographic follow-up (median, 24 months) for benign lesions was used to determine results. Three forms of diagnostic discrimination measures (strict, working [strict conditioned by tissue sampling error], applied [working conditioned by concordance of imaging and CNB findings) were used to evaluate the correlation of CNB, surgical, and follow-up results. RESULTS: Strict, working, and applied sensitivities were 91{\%} ± 1.9; 92{\%} ± 1.8, and 98{\%} ± 0.9, respectively; strict, working, and applied specificities were 100{\%}, 98{\%} ± 0.8, and 73{\%} ± 0.9; strict, working, and applied accuracies were 97{\%}, 96{\%}, and 79{\%}. CONCLUSION: Percutaneous stereotactic CNB is an accurate method to establish a histopathologic diagnosis of nonpalpable breast lesions. Accuracy increases when additional surgery is performed for lesions with anticipated sampling error or when CNB findings are discordant with mammographic findings. An understanding of the interrelationship among these parameters is necessary to properly assess results.",
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T1 - Stereotactic core-needle breast biopsy

T2 - A multi-institutional prospective trial

AU - Brenner, R. J.

AU - Bassett, L. W.

AU - Fajardo, L. L.

AU - Dershaw, D. D.

AU - Evans, W. P.

AU - Hunt, R.

AU - Lee, C.

AU - Tocino, I.

AU - Fisher, P.

AU - McCombs, M.

AU - Jackson, Valerie

AU - Feig, S. A.

AU - Mendelson, E. B.

AU - Margolin, F. R.

AU - Bird, R.

AU - Sayre, J.

PY - 2001

Y1 - 2001

N2 - PURPOSE: To assess the accuracy of stereotactic core-needle biopsy (CNB) of nonpalpable breast lesions within the context of clinically important parameters of anticipated tissue-sampling error and concordance with mammographic findings. MATERIALS AND METHODS: CNB was performed in 1,003 patients, with results validated at surgery or clinical and mammographic follow-up. Mammographic findings were scored according to the American College of Radiology Breast Imaging Reporting and Data System with a similar correlative scale for histopathologic samples obtained at either CNB or surgery. Agreement of CNB findings With surgical findings or evidence of no change during clinical and mammographic follow-up (median, 24 months) for benign lesions was used to determine results. Three forms of diagnostic discrimination measures (strict, working [strict conditioned by tissue sampling error], applied [working conditioned by concordance of imaging and CNB findings) were used to evaluate the correlation of CNB, surgical, and follow-up results. RESULTS: Strict, working, and applied sensitivities were 91% ± 1.9; 92% ± 1.8, and 98% ± 0.9, respectively; strict, working, and applied specificities were 100%, 98% ± 0.8, and 73% ± 0.9; strict, working, and applied accuracies were 97%, 96%, and 79%. CONCLUSION: Percutaneous stereotactic CNB is an accurate method to establish a histopathologic diagnosis of nonpalpable breast lesions. Accuracy increases when additional surgery is performed for lesions with anticipated sampling error or when CNB findings are discordant with mammographic findings. An understanding of the interrelationship among these parameters is necessary to properly assess results.

AB - PURPOSE: To assess the accuracy of stereotactic core-needle biopsy (CNB) of nonpalpable breast lesions within the context of clinically important parameters of anticipated tissue-sampling error and concordance with mammographic findings. MATERIALS AND METHODS: CNB was performed in 1,003 patients, with results validated at surgery or clinical and mammographic follow-up. Mammographic findings were scored according to the American College of Radiology Breast Imaging Reporting and Data System with a similar correlative scale for histopathologic samples obtained at either CNB or surgery. Agreement of CNB findings With surgical findings or evidence of no change during clinical and mammographic follow-up (median, 24 months) for benign lesions was used to determine results. Three forms of diagnostic discrimination measures (strict, working [strict conditioned by tissue sampling error], applied [working conditioned by concordance of imaging and CNB findings) were used to evaluate the correlation of CNB, surgical, and follow-up results. RESULTS: Strict, working, and applied sensitivities were 91% ± 1.9; 92% ± 1.8, and 98% ± 0.9, respectively; strict, working, and applied specificities were 100%, 98% ± 0.8, and 73% ± 0.9; strict, working, and applied accuracies were 97%, 96%, and 79%. CONCLUSION: Percutaneous stereotactic CNB is an accurate method to establish a histopathologic diagnosis of nonpalpable breast lesions. Accuracy increases when additional surgery is performed for lesions with anticipated sampling error or when CNB findings are discordant with mammographic findings. An understanding of the interrelationship among these parameters is necessary to properly assess results.

KW - Breast neoplasms, diagnosis

KW - Breast radiography, utilization

KW - Breast, biopsy

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VL - 218

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EP - 872

JO - Radiology

JF - Radiology

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