Sticky Platelet Syndrome

An Unusual Presentation of Arterial Ischemia

M. O. Bojalian, A. G. Akingba, J. C. Andersen, P. S. Swerdlow, P. G. Bove, O. W. Brown, J. R. Rubin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A 48-year-old woman presented with bilateral lower extremity critical limb ischemia. In addition to this, her work-up revealed multiple other thromboembolic insults including cerebral and visceral emboli. Initial laboratory findings were significant for an indeterminate platelet count, secondary to platelet clumping. After appropriate emergent surgical treatment including bilateral lower extremity embolectomy, the patient was empirically anticoagulated with a direct thrombin inhibitor. Further embolic work-up discovered bilateral renal and splenic infarctions as well as a large mobile mitral vegetation. Finally, an upper extremity duplex revealed left axillary, left subclavian, and right internal jugular acute deep vein thromboses. Mitral valve replacement was performed to remove the septic source. A series of hypercoagulability studies was done, and results were positive for lupus anticoagulants. Months after her recovery, the patient was tested and found to be positive for sticky platelet syndrome.

Original languageEnglish (US)
JournalAnnals of Vascular Surgery
Volume24
Issue number5
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

Lower Extremity
Blood Platelets
Ischemia
Splenic Infarction
Embolectomy
Intracranial Embolism
Lupus Coagulation Inhibitor
Thrombophilia
Antithrombins
Platelet Count
Mitral Valve
Upper Extremity
Venous Thrombosis
Neck
Extremities
Kidney
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Bojalian, M. O., Akingba, A. G., Andersen, J. C., Swerdlow, P. S., Bove, P. G., Brown, O. W., & Rubin, J. R. (2010). Sticky Platelet Syndrome: An Unusual Presentation of Arterial Ischemia. Annals of Vascular Surgery, 24(5). https://doi.org/10.1016/j.avsg.2009.12.005

Sticky Platelet Syndrome : An Unusual Presentation of Arterial Ischemia. / Bojalian, M. O.; Akingba, A. G.; Andersen, J. C.; Swerdlow, P. S.; Bove, P. G.; Brown, O. W.; Rubin, J. R.

In: Annals of Vascular Surgery, Vol. 24, No. 5, 07.2010.

Research output: Contribution to journalArticle

Bojalian, MO, Akingba, AG, Andersen, JC, Swerdlow, PS, Bove, PG, Brown, OW & Rubin, JR 2010, 'Sticky Platelet Syndrome: An Unusual Presentation of Arterial Ischemia', Annals of Vascular Surgery, vol. 24, no. 5. https://doi.org/10.1016/j.avsg.2009.12.005
Bojalian MO, Akingba AG, Andersen JC, Swerdlow PS, Bove PG, Brown OW et al. Sticky Platelet Syndrome: An Unusual Presentation of Arterial Ischemia. Annals of Vascular Surgery. 2010 Jul;24(5). https://doi.org/10.1016/j.avsg.2009.12.005
Bojalian, M. O. ; Akingba, A. G. ; Andersen, J. C. ; Swerdlow, P. S. ; Bove, P. G. ; Brown, O. W. ; Rubin, J. R. / Sticky Platelet Syndrome : An Unusual Presentation of Arterial Ischemia. In: Annals of Vascular Surgery. 2010 ; Vol. 24, No. 5.
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