Stimulation of calcitonin synthesis and release in vitro by calcium and dibutyryl cyclic AMP

Norman H. Bell, Sherry Queener

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

IT has been proposed that the physiological action of calcitonin is to prevent or diminish postprandial hypercalcaemia1. This is accomplished by inhibition of bone resorption2, of the tubular reabsorption of calcium3, and of the intestinal absorption of calcium4. Secretion or release of the hormone by parafollicular cells of the thyroid gland is mediated by calcium5-7 and by gastrointestinal hormones including gastrin and pancreozymin8,9. Secretion is apparently influenced by the adenylate cyclase system 7,10 and hormonal regulation presumably is mediated by cyclic adenosine 3′, 5′-monophosphate (cyclic AMP).

Original languageEnglish (US)
Pages (from-to)343-344
Number of pages2
JournalNature
Volume248
Issue number5446
DOIs
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • General

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