Stimulation of reticuloendothelial system and toxicity to macrophages of Staphylococcus aureus cell wall, peptidoglycan, and teichoic acid

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Abstract

Staphylococcus aureus cell walls possess several biologic activities. They are removed from the blood by the RES and persist there for a long time. The influence of cell wall components on RES cells in vivo and in vitro was investigated. RES activity was studied in mice by the carbon clearance method. I.v. injection of 10 μg of a cell wall fraction or peptidoglycan caused early stimulation and subsequent suppression of RES activity, while teichoic acid was inactive; 400 μg of peptidoglycan caused RES stimulation with a maximum after 3 days, whereas 400 μg of cell walls caused no such stimulation. Viability of mouse peritoneal macrophages was studied after 4 days of culture in the presence of cell walls, peptidoglycan, and teichoic acid. 50 μg/ml of cell walls or peptidoglycan caused death of all or 68% of macrophages respectively. Teichoic acid was inactive, exhibiting toxic effects at 400 μg/ml level.

Original languageEnglish (US)
Pages (from-to)320-329
Number of pages10
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume238
Issue number3
StatePublished - Dec 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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