Stochastic resonance in osteogenic response to mechanical loading.

Shigeo M. Tanaka, Imranul M. Alam, Charles H. Turner

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Stochastic resonance, in which noise enhances the response of a nonlinear system to a weak signal, has been observed in various biological sensory systems. We speculated that bone formation in response to mechanical loading could be enhanced by adding noise (vibration) to a standard exercise regimen. To test this hypothesis, three different loading regimens were applied to the ulnae of mice: (1) high amplitude, low frequency sinusoidal loading at 2 Hz with an amplitude of 3 N to simulate exercise; (2) low amplitude, broad frequency vibration with frequency components 0-50 Hz and 0.3 N of mean amplitude; (3) the sinusoidal wave combined with vibration (S+V) to invoke stochastic resonance. The simulated exercise regimen induced new bone formation on the periosteal surface of the ulna, however the addition of vibration noise with exercise enhanced the osteogenic response by almost 4-fold. Vibration by itself had no effect on bone formation. It was concluded that adding low magnitude vibration greatly enhanced bone formation in response to loading, suggesting a contribution of stochastic resonance in the osteogenic response.

Original languageEnglish (US)
Pages (from-to)313-314
Number of pages2
JournalThe FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume17
Issue number2
StatePublished - Feb 2003

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Stochastic resonance in osteogenic response to mechanical loading.'. Together they form a unique fingerprint.

  • Cite this