Strain differences in pituitary β-endorphin and ACTH content in inbred mice

John C. Crabbe, Richard G. Allen, N. Donna Gaudette, Emmett R. Young, Ann Kosobud, Julianne Stack

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The whole pituitary contents of β-endorphin and ACTH were found to vary widely among 5 inbred strains of mice. β-endorphin values were 2.5-fold different and ACTH values 1.5-fold. Strains low in β-endorphin were also low in ACTH. The existence of genetic differences raises the possibility that there exist, or can be developed, strains with extremely low or high levels of these peptides that would aid research directed at elucidating the physiology of opioid peptides.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalBrain research
Volume219
Issue number1
DOIs
StatePublished - Aug 24 1981
Externally publishedYes

Keywords

  • gel electrophoresis
  • mouse inbred strain
  • pharmacogenetic
  • pituitary
  • radioimmunoassay
  • strain difference
  • β-endorphine content

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Crabbe, J. C., Allen, R. G., Gaudette, N. D., Young, E. R., Kosobud, A., & Stack, J. (1981). Strain differences in pituitary β-endorphin and ACTH content in inbred mice. Brain research, 219(1), 219-223. https://doi.org/10.1016/0006-8993(81)90286-9