Strain differences in the ontogeny of estrogen receptors in murine uterine epithelium

Robert Bigsby, Li Aixin, Kenneth Luo, Gerald R. Cunha

Research output: Contribution to journalArticle

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Abstract

The expression of estrogen receptor (ER) in the reproductive tracts of neonatal mice was examined using immunocytochemical and autoradiographic methods. Two strains of mice used in previous studies that reported contradictory results showed different rates of uterine epithelial development. In the inbred strain, BALB/c, the epithelium was devoid of receptor from birth through 5 days of age, while uterine epithelial cells of the outbred strain, CD-1, expressed ER as early as 3 days of age. Oviductal epithelium and cervical epithelium expressed ER on the day of birth in CD-1 mice. Glandular ontogeny in the uteri of CD-1 animals was also advanced by 3 days compared to that of BALB/c mice. These observations reconcile the conflicting reports of ER ontogeny in the neonatal mouse. More importantly, these results confirm our earlier observations, indicating that the cells lining uteri of 2- and 4-day-old BALB/c mice lack ER at a time when estrogen induces their proliferation.

Original languageEnglish
Pages (from-to)2592-2596
Number of pages5
JournalEndocrinology
Volume126
Issue number5
StatePublished - May 1990

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Estrogen Receptors
Epithelium
Uterus
Parturition
Estrogens
Epithelial Cells

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Strain differences in the ontogeny of estrogen receptors in murine uterine epithelium. / Bigsby, Robert; Aixin, Li; Luo, Kenneth; Cunha, Gerald R.

In: Endocrinology, Vol. 126, No. 5, 05.1990, p. 2592-2596.

Research output: Contribution to journalArticle

Bigsby, R, Aixin, L, Luo, K & Cunha, GR 1990, 'Strain differences in the ontogeny of estrogen receptors in murine uterine epithelium', Endocrinology, vol. 126, no. 5, pp. 2592-2596.
Bigsby, Robert ; Aixin, Li ; Luo, Kenneth ; Cunha, Gerald R. / Strain differences in the ontogeny of estrogen receptors in murine uterine epithelium. In: Endocrinology. 1990 ; Vol. 126, No. 5. pp. 2592-2596.
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