Strategies for Myocardial Repair

GOU YOUNG KOH, MARK H. SOONPAA, MICHAEL G. KLUG, LOREN J. FIELD

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The therapeutic recourse for end-stage heart disease is currently limited to cardiac transplantation. The ability to augment cardimyocyte number in an end-stage heart might facilitate myocardial function. Augmentation of cardiomyocyte number may be achievable by the targeted expression of cell cycle regulatory genes to the myocardium. Alternatively, intracardiac grafting of exogenous cardiomyocytes might also provide a viable approach to augment cardiomyocyte number. Potential strategies for heart muscle regeneration via gene therapy and cellular transplantation are discussed.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalJournal of interventional cardiology
Volume8
Issue number4
DOIs
StatePublished - Aug 1995

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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