Allelic replacement of the C terminus of a Streptococcus mutans surface protein affects murein nydrolase activity. The targeted open reading frame encodes a 67-kDa protein (SmaA) with an N-terminal signal sequence and cleavage site, three 46-amino-acid (aa) direct repeats, and two 88-aa direct repeats. The identical autolytic profile was obtained using a sortase mutant (SrtA -).
ASJC Scopus subject areas
- Molecular Biology