Streptokinase was infused through the partially thrombosed Tenckhoff catheters of four children on continuous ambulatory peritoneal dialyis (CAPD). Radiographic contrast studies performed before and after the infusions demonstrated dramatic dissolution of the fibrin thrombi associated with restoration of normal catheter function. The catheters subsequently functioned for an average of 12.5 months. No allergic or hemorrhagic complications were noted in association with the infusions. Coagulation studies revealed no evidence for systemic streptokinase absorption. We suggest that streptokinase, when given in the manner described, is a safe and effective treatment of thrombosed Tenckhoff catheters in children.
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