Stress, Panic, and Central Serotonergic Inhibition

J. E. Hassell, P. S.M. Yamashita, Philip Johnson, H. Zangrossi, Anantha Shekhar, C. A. Lowry

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

Panic disorder (PD) is an anxiety disorder associated with the occurrence of panic attacks, which arise suddenly without warning. Panic disorder represents a serious psychiatric condition and it can induce complications related to the fear of having subsequent panic attacks and avoidance behaviors. Given its importance, many studies have been conducted to elucidate the circuitry involved in this disorder. Clinical and preclinical studies suggest that PD can be modulated by a specific network of brain structures controlling emotional behaviors and autonomic responses. Using animal models that allow measurement of responses related to behavioral and autonomic symptoms of panic attacks in humans, it has been shown that the neuromodulator serotonin plays an inhibitory role in control of panic attacks associated with PD. Understanding the pathways through which serotonergic systems modulate panic-like responses is key to understanding the biological basis of panic attacks and PD, and, consequently, to establishing novel therapeutic strategies for treatment of PD.

Original languageEnglish (US)
Title of host publicationHandbook of Stress Series
PublisherElsevier Inc.
Pages153-164
Number of pages12
Volume2
ISBN (Electronic)9780128024232
ISBN (Print)9780128021750
DOIs
StatePublished - Jan 13 2017

Fingerprint

Panic
Panic Disorder
Inhibition (Psychology)
Avoidance Learning
Behavioral Symptoms
Anxiety Disorders
Fear
Neurotransmitter Agents
Psychiatry
Serotonin
Animal Models

Keywords

  • Basolateral amygdala
  • Escape
  • Hypothalamus
  • Panic attack
  • Panic disorder
  • Panicolytic
  • Periaqueductal gray
  • Raphe
  • Rostral ventrolateral medulla
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hassell, J. E., Yamashita, P. S. M., Johnson, P., Zangrossi, H., Shekhar, A., & Lowry, C. A. (2017). Stress, Panic, and Central Serotonergic Inhibition. In Handbook of Stress Series (Vol. 2, pp. 153-164). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802175-0.00015-2

Stress, Panic, and Central Serotonergic Inhibition. / Hassell, J. E.; Yamashita, P. S.M.; Johnson, Philip; Zangrossi, H.; Shekhar, Anantha; Lowry, C. A.

Handbook of Stress Series. Vol. 2 Elsevier Inc., 2017. p. 153-164.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hassell, JE, Yamashita, PSM, Johnson, P, Zangrossi, H, Shekhar, A & Lowry, CA 2017, Stress, Panic, and Central Serotonergic Inhibition. in Handbook of Stress Series. vol. 2, Elsevier Inc., pp. 153-164. https://doi.org/10.1016/B978-0-12-802175-0.00015-2
Hassell JE, Yamashita PSM, Johnson P, Zangrossi H, Shekhar A, Lowry CA. Stress, Panic, and Central Serotonergic Inhibition. In Handbook of Stress Series. Vol. 2. Elsevier Inc. 2017. p. 153-164 https://doi.org/10.1016/B978-0-12-802175-0.00015-2
Hassell, J. E. ; Yamashita, P. S.M. ; Johnson, Philip ; Zangrossi, H. ; Shekhar, Anantha ; Lowry, C. A. / Stress, Panic, and Central Serotonergic Inhibition. Handbook of Stress Series. Vol. 2 Elsevier Inc., 2017. pp. 153-164
@inbook{e57a934e9cd542c1a374079e10f4a478,
title = "Stress, Panic, and Central Serotonergic Inhibition",
abstract = "Panic disorder (PD) is an anxiety disorder associated with the occurrence of panic attacks, which arise suddenly without warning. Panic disorder represents a serious psychiatric condition and it can induce complications related to the fear of having subsequent panic attacks and avoidance behaviors. Given its importance, many studies have been conducted to elucidate the circuitry involved in this disorder. Clinical and preclinical studies suggest that PD can be modulated by a specific network of brain structures controlling emotional behaviors and autonomic responses. Using animal models that allow measurement of responses related to behavioral and autonomic symptoms of panic attacks in humans, it has been shown that the neuromodulator serotonin plays an inhibitory role in control of panic attacks associated with PD. Understanding the pathways through which serotonergic systems modulate panic-like responses is key to understanding the biological basis of panic attacks and PD, and, consequently, to establishing novel therapeutic strategies for treatment of PD.",
keywords = "Basolateral amygdala, Escape, Hypothalamus, Panic attack, Panic disorder, Panicolytic, Periaqueductal gray, Raphe, Rostral ventrolateral medulla, Serotonin",
author = "Hassell, {J. E.} and Yamashita, {P. S.M.} and Philip Johnson and H. Zangrossi and Anantha Shekhar and Lowry, {C. A.}",
year = "2017",
month = "1",
day = "13",
doi = "10.1016/B978-0-12-802175-0.00015-2",
language = "English (US)",
isbn = "9780128021750",
volume = "2",
pages = "153--164",
booktitle = "Handbook of Stress Series",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Stress, Panic, and Central Serotonergic Inhibition

AU - Hassell, J. E.

AU - Yamashita, P. S.M.

AU - Johnson, Philip

AU - Zangrossi, H.

AU - Shekhar, Anantha

AU - Lowry, C. A.

PY - 2017/1/13

Y1 - 2017/1/13

N2 - Panic disorder (PD) is an anxiety disorder associated with the occurrence of panic attacks, which arise suddenly without warning. Panic disorder represents a serious psychiatric condition and it can induce complications related to the fear of having subsequent panic attacks and avoidance behaviors. Given its importance, many studies have been conducted to elucidate the circuitry involved in this disorder. Clinical and preclinical studies suggest that PD can be modulated by a specific network of brain structures controlling emotional behaviors and autonomic responses. Using animal models that allow measurement of responses related to behavioral and autonomic symptoms of panic attacks in humans, it has been shown that the neuromodulator serotonin plays an inhibitory role in control of panic attacks associated with PD. Understanding the pathways through which serotonergic systems modulate panic-like responses is key to understanding the biological basis of panic attacks and PD, and, consequently, to establishing novel therapeutic strategies for treatment of PD.

AB - Panic disorder (PD) is an anxiety disorder associated with the occurrence of panic attacks, which arise suddenly without warning. Panic disorder represents a serious psychiatric condition and it can induce complications related to the fear of having subsequent panic attacks and avoidance behaviors. Given its importance, many studies have been conducted to elucidate the circuitry involved in this disorder. Clinical and preclinical studies suggest that PD can be modulated by a specific network of brain structures controlling emotional behaviors and autonomic responses. Using animal models that allow measurement of responses related to behavioral and autonomic symptoms of panic attacks in humans, it has been shown that the neuromodulator serotonin plays an inhibitory role in control of panic attacks associated with PD. Understanding the pathways through which serotonergic systems modulate panic-like responses is key to understanding the biological basis of panic attacks and PD, and, consequently, to establishing novel therapeutic strategies for treatment of PD.

KW - Basolateral amygdala

KW - Escape

KW - Hypothalamus

KW - Panic attack

KW - Panic disorder

KW - Panicolytic

KW - Periaqueductal gray

KW - Raphe

KW - Rostral ventrolateral medulla

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=85021933115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021933115&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-802175-0.00015-2

DO - 10.1016/B978-0-12-802175-0.00015-2

M3 - Chapter

AN - SCOPUS:85021933115

SN - 9780128021750

VL - 2

SP - 153

EP - 164

BT - Handbook of Stress Series

PB - Elsevier Inc.

ER -