Stress response proteins and renal ischemia

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Acute renal failure is a frequent clinical entity with an increasing incidence and an unacceptably high mortality, yet there is no specific treatment. The induction of stress response (heat shock) proteins (HSPs) is a highly conserved response that protects many cell types from diverse physiological and environmental stressors. Diverse HSP families of different sizes function as molecular chaperones that facilitate the folding of enzymes and other proteins into the functional conformation. After injury, HSPs are believed to facilitate the restoration of normal function by assisting in the refolding of denatured proteins and degradation of irreparably damaged proteins and toxic metabolites, limitation of aggregation of damaged peptides and aiding the appropriate folding of newly synthesized essential polypeptides. We have recently demonstrated protection from the functional deficits and histologic evidence of experimental ischemic renal injury with heat stress 6 hours but not 48 hours prior to the ischemic insult. Limitation of the induction of HSPs (either with a short period of hyperthermia or pharmacologically) attenuated the protection observed. Other investigators have demonstrated a correlation between the levels of HSP 25 and renal ischemic preconditioning in the mouse. Several pharmacologic agents have been shown to increase HSP expression. Enhancement of these endogenous protective mechanisms has potential benefit in human disease.

Original languageEnglish
Pages (from-to)81-91
Number of pages11
JournalMinerva Urologica e Nefrologica
Volume54
Issue number2
StatePublished - Jun 2002

Fingerprint

Heat-Shock Proteins
Ischemia
Kidney
Ischemic Preconditioning
Peptides
Molecular Chaperones
Poisons
Wounds and Injuries
Acute Kidney Injury
Proteolysis
Proteins
Fever
Hot Temperature
Research Personnel
Mortality
Incidence
Enzymes

Keywords

  • Ischemia, physiology
  • Ischemic preconditioning
  • Kidney

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Stress response proteins and renal ischemia. / Kelly, Katherine.

In: Minerva Urologica e Nefrologica, Vol. 54, No. 2, 06.2002, p. 81-91.

Research output: Contribution to journalArticle

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