Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information

Shalmali Dharmadhikari, Ruoyun Ma, Chien Lin Yeh, Ann Kathrin Stock, Sandy Snyder, S. Zauber, Ulrike Dydak, Christian Beste

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The selection of appropriate responses is a complex endeavor requiring the integration of many different sources of information in fronto-striatal-thalamic circuits. An often neglected but relevant piece of information is provided by proprioceptive inputs about the current position of our limbs. This study examines the importance of striatal and thalamic GABA levels in these processes using GABA-edited magnetic resonance spectroscopy (GABA-MRS) and a Simon task featuring proprioception-induced interference in healthy subjects. As a possible model of deficits in the processing of proprioceptive information, we also included Parkinson's disease (PD) patients in this study.The results show that proprioceptive information about unusual postures complicates response selection processes in controls, but not in PD patients. The well-known deficits of PD patients in processing proprioceptive information can turn into a benefit when altered proprioceptive information would normally complicate response selection processes. Striatal and thalamic GABA levels play dissociable roles in the modulation of response selection processes by proprioceptive information: Striatal GABA levels seem to be important for the general speed of responding, most likely because striatal GABA promotes response selection. In contrast, the modulation of response conflict by proprioceptive information is closely related to thalamic GABA concentrations with higher concentration being related to a smaller response conflict effect. The most likely explanation for this finding is that the thalamus is involved in the integration of sensorimotor, attentional, and cognitive information for the purpose of response formation. Yet, this effect in the thalamus vanishes when controls and PD patients were analyzed separately.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalNeuroImage
Volume120
DOIs
StatePublished - Oct 5 2015

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Corpus Striatum
gamma-Aminobutyric Acid
Parkinson Disease
Thalamus
Automatic Data Processing
Proprioception
Posture
Healthy Volunteers
Magnetic Resonance Spectroscopy
Extremities

Keywords

  • GABA
  • Parkinson's disease
  • Proprioception
  • Response selection
  • Sensorimotor integration
  • Striatum
  • Thalamus

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information. / Dharmadhikari, Shalmali; Ma, Ruoyun; Yeh, Chien Lin; Stock, Ann Kathrin; Snyder, Sandy; Zauber, S.; Dydak, Ulrike; Beste, Christian.

In: NeuroImage, Vol. 120, 05.10.2015, p. 36-42.

Research output: Contribution to journalArticle

Dharmadhikari, Shalmali ; Ma, Ruoyun ; Yeh, Chien Lin ; Stock, Ann Kathrin ; Snyder, Sandy ; Zauber, S. ; Dydak, Ulrike ; Beste, Christian. / Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information. In: NeuroImage. 2015 ; Vol. 120. pp. 36-42.
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