Striatal D2/D3 receptor availability is inversely correlated with cannabis consumption in chronic marijuana users

Daniel S. Albrecht, Patrick D. Skosnik, Jennifer M. Vollmer, Margaret S. Brumbaugh, Kevin M. Perry, Bruce H. Mock, Qi-Huang Zheng, Lauren A. Federici, Elizabeth A. Patton, Christine M. Herring, Karmen Yoder

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Although the incidence of cannabis abuse/dependence in Americans is rising, the neurobiology of cannabis addiction is not well understood. Imaging studies have demonstrated deficits in striatal D2/D3 receptor availability in several substance-dependent populations. However, this has not been studied in currently using chronic cannabis users. Objective: The purpose of this study was to compare striatal D2/D3 receptor availability between currently using chronic cannabis users and healthy controls. Methods: Eighteen right-handed males age 18-34 were studied. Ten subjects were chronic cannabis users; eight were demographically matched controls. Subjects underwent a [11C]raclopride (RAC) PET scan. Striatal RAC binding potential (BPND) was calculated on a voxel-wise basis. Prior to scanning, urine samples were obtained from cannabis users for quantification of urine Δ-9-tetrahydrocannabinol (THC) and THC metabolites (11-nor-Δ-9-THC-9-carboxylic acid; THC-COOH and 11-hydroxy-THC;OH-THC). Results: There were no differences in D2/D3 receptor availability between cannabis users and controls. Voxel-wise analyses revealed that RAC BPND values were negatively associated with both urine levels of cannabis metabolites and self-report of recent cannabis consumption. Conclusions: In this sample, current cannabis use was not associated with deficits in striatal D2/D3 receptor availability. There was an inverse relationship between chronic cannabis use and striatal RAC BPND. Additional studies are needed to identify the neurochemical consequences of chronic cannabis use on the dopamine system.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalDrug and Alcohol Dependence
Volume128
Issue number1-2
DOIs
StatePublished - Feb 1 2013

Fingerprint

Corpus Striatum
Cannabis
Availability
Dronabinol
Raclopride
Marijuana Abuse
Urine
Metabolites
Neurobiology
Carboxylic Acids
Positron-Emission Tomography
Self Report
Dopamine

Keywords

  • Cannabis
  • D receptor
  • Dopamine
  • Marijuana
  • Positron emission tomography
  • Raclopride

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Toxicology
  • Pharmacology
  • Pharmacology (medical)

Cite this

Striatal D2/D3 receptor availability is inversely correlated with cannabis consumption in chronic marijuana users. / Albrecht, Daniel S.; Skosnik, Patrick D.; Vollmer, Jennifer M.; Brumbaugh, Margaret S.; Perry, Kevin M.; Mock, Bruce H.; Zheng, Qi-Huang; Federici, Lauren A.; Patton, Elizabeth A.; Herring, Christine M.; Yoder, Karmen.

In: Drug and Alcohol Dependence, Vol. 128, No. 1-2, 01.02.2013, p. 52-57.

Research output: Contribution to journalArticle

Albrecht, DS, Skosnik, PD, Vollmer, JM, Brumbaugh, MS, Perry, KM, Mock, BH, Zheng, Q-H, Federici, LA, Patton, EA, Herring, CM & Yoder, K 2013, 'Striatal D2/D3 receptor availability is inversely correlated with cannabis consumption in chronic marijuana users', Drug and Alcohol Dependence, vol. 128, no. 1-2, pp. 52-57. https://doi.org/10.1016/j.drugalcdep.2012.07.016
Albrecht, Daniel S. ; Skosnik, Patrick D. ; Vollmer, Jennifer M. ; Brumbaugh, Margaret S. ; Perry, Kevin M. ; Mock, Bruce H. ; Zheng, Qi-Huang ; Federici, Lauren A. ; Patton, Elizabeth A. ; Herring, Christine M. ; Yoder, Karmen. / Striatal D2/D3 receptor availability is inversely correlated with cannabis consumption in chronic marijuana users. In: Drug and Alcohol Dependence. 2013 ; Vol. 128, No. 1-2. pp. 52-57.
@article{09a4926c37234af1a8fa2ab3d922a8dd,
title = "Striatal D2/D3 receptor availability is inversely correlated with cannabis consumption in chronic marijuana users",
abstract = "Background: Although the incidence of cannabis abuse/dependence in Americans is rising, the neurobiology of cannabis addiction is not well understood. Imaging studies have demonstrated deficits in striatal D2/D3 receptor availability in several substance-dependent populations. However, this has not been studied in currently using chronic cannabis users. Objective: The purpose of this study was to compare striatal D2/D3 receptor availability between currently using chronic cannabis users and healthy controls. Methods: Eighteen right-handed males age 18-34 were studied. Ten subjects were chronic cannabis users; eight were demographically matched controls. Subjects underwent a [11C]raclopride (RAC) PET scan. Striatal RAC binding potential (BPND) was calculated on a voxel-wise basis. Prior to scanning, urine samples were obtained from cannabis users for quantification of urine Δ-9-tetrahydrocannabinol (THC) and THC metabolites (11-nor-Δ-9-THC-9-carboxylic acid; THC-COOH and 11-hydroxy-THC;OH-THC). Results: There were no differences in D2/D3 receptor availability between cannabis users and controls. Voxel-wise analyses revealed that RAC BPND values were negatively associated with both urine levels of cannabis metabolites and self-report of recent cannabis consumption. Conclusions: In this sample, current cannabis use was not associated with deficits in striatal D2/D3 receptor availability. There was an inverse relationship between chronic cannabis use and striatal RAC BPND. Additional studies are needed to identify the neurochemical consequences of chronic cannabis use on the dopamine system.",
keywords = "Cannabis, D receptor, Dopamine, Marijuana, Positron emission tomography, Raclopride",
author = "Albrecht, {Daniel S.} and Skosnik, {Patrick D.} and Vollmer, {Jennifer M.} and Brumbaugh, {Margaret S.} and Perry, {Kevin M.} and Mock, {Bruce H.} and Qi-Huang Zheng and Federici, {Lauren A.} and Patton, {Elizabeth A.} and Herring, {Christine M.} and Karmen Yoder",
year = "2013",
month = "2",
day = "1",
doi = "10.1016/j.drugalcdep.2012.07.016",
language = "English",
volume = "128",
pages = "52--57",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Striatal D2/D3 receptor availability is inversely correlated with cannabis consumption in chronic marijuana users

AU - Albrecht, Daniel S.

AU - Skosnik, Patrick D.

AU - Vollmer, Jennifer M.

AU - Brumbaugh, Margaret S.

AU - Perry, Kevin M.

AU - Mock, Bruce H.

AU - Zheng, Qi-Huang

AU - Federici, Lauren A.

AU - Patton, Elizabeth A.

AU - Herring, Christine M.

AU - Yoder, Karmen

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Background: Although the incidence of cannabis abuse/dependence in Americans is rising, the neurobiology of cannabis addiction is not well understood. Imaging studies have demonstrated deficits in striatal D2/D3 receptor availability in several substance-dependent populations. However, this has not been studied in currently using chronic cannabis users. Objective: The purpose of this study was to compare striatal D2/D3 receptor availability between currently using chronic cannabis users and healthy controls. Methods: Eighteen right-handed males age 18-34 were studied. Ten subjects were chronic cannabis users; eight were demographically matched controls. Subjects underwent a [11C]raclopride (RAC) PET scan. Striatal RAC binding potential (BPND) was calculated on a voxel-wise basis. Prior to scanning, urine samples were obtained from cannabis users for quantification of urine Δ-9-tetrahydrocannabinol (THC) and THC metabolites (11-nor-Δ-9-THC-9-carboxylic acid; THC-COOH and 11-hydroxy-THC;OH-THC). Results: There were no differences in D2/D3 receptor availability between cannabis users and controls. Voxel-wise analyses revealed that RAC BPND values were negatively associated with both urine levels of cannabis metabolites and self-report of recent cannabis consumption. Conclusions: In this sample, current cannabis use was not associated with deficits in striatal D2/D3 receptor availability. There was an inverse relationship between chronic cannabis use and striatal RAC BPND. Additional studies are needed to identify the neurochemical consequences of chronic cannabis use on the dopamine system.

AB - Background: Although the incidence of cannabis abuse/dependence in Americans is rising, the neurobiology of cannabis addiction is not well understood. Imaging studies have demonstrated deficits in striatal D2/D3 receptor availability in several substance-dependent populations. However, this has not been studied in currently using chronic cannabis users. Objective: The purpose of this study was to compare striatal D2/D3 receptor availability between currently using chronic cannabis users and healthy controls. Methods: Eighteen right-handed males age 18-34 were studied. Ten subjects were chronic cannabis users; eight were demographically matched controls. Subjects underwent a [11C]raclopride (RAC) PET scan. Striatal RAC binding potential (BPND) was calculated on a voxel-wise basis. Prior to scanning, urine samples were obtained from cannabis users for quantification of urine Δ-9-tetrahydrocannabinol (THC) and THC metabolites (11-nor-Δ-9-THC-9-carboxylic acid; THC-COOH and 11-hydroxy-THC;OH-THC). Results: There were no differences in D2/D3 receptor availability between cannabis users and controls. Voxel-wise analyses revealed that RAC BPND values were negatively associated with both urine levels of cannabis metabolites and self-report of recent cannabis consumption. Conclusions: In this sample, current cannabis use was not associated with deficits in striatal D2/D3 receptor availability. There was an inverse relationship between chronic cannabis use and striatal RAC BPND. Additional studies are needed to identify the neurochemical consequences of chronic cannabis use on the dopamine system.

KW - Cannabis

KW - D receptor

KW - Dopamine

KW - Marijuana

KW - Positron emission tomography

KW - Raclopride

UR - http://www.scopus.com/inward/record.url?scp=84872378144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872378144&partnerID=8YFLogxK

U2 - 10.1016/j.drugalcdep.2012.07.016

DO - 10.1016/j.drugalcdep.2012.07.016

M3 - Article

C2 - 22909787

AN - SCOPUS:84872378144

VL - 128

SP - 52

EP - 57

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

IS - 1-2

ER -