Strong gastric contractions cause mucosal ischemia

E. H. Livingston, T. J. Howard, T. R. Garrick, E. P. Passaro, P. H. Guth

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Contractions of a segment of bowel result in alterations of its blood flow. However, the precise temporal and spacial relationships between contractions and mucosal blood flow are unknown. Rats were fitted with strain gauge force transducers and implanted with silver wire electrodes into the muscularis externa of the stomach. In vivo microscopic observation of motility and of the gastric mucosal blood flow was performed during electrical field-stimulated contractions. Contractions originated in the midcorpus, were 0.237 ± 0.018 cm wide, traveled along the corpus at 0.133 ± 0.024 cm/s, and had a duration of 5.9 ± 0.1 s. Antral contractions were 0.174 ± 0.032 cm wide, traveled at 0.070 ± 0.009 cm/s, and had a duration of 5.6 ± 0.7 s. During the contraction, capillary flow velocity in the corpus decreased from a basal value of 410 ± 105 to 206 ± 104 μm/s at the peak of a contraction. Five seconds after the contraction was released hyperemia was observed with the flow sease.

Original languageEnglish (US)
Pages (from-to)G524-G530
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume260
Issue number3 23-3
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • Electrical field stimulation
  • Gastric contraction propagation
  • Gastric motility
  • Gastrointestinal blood flow

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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