Strong gastric contractions cause mucosal ischemia

E. H. Livingston, T. J. Howard, T. R. Garrick, E. P. Passaro, P. H. Guth

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Contractions of a segment of bowel result in alterations of its blood flow. However, the precise temporal and spacial relationships between contractions and mucosal blood flow are unknown. Rats were fitted with strain gauge force transducers and implanted with silver wire electrodes into the muscularis externa of the stomach. In vivo microscopic observation of motility and of the gastric mucosal blood flow was performed during electrical field-stimulated contractions. Contractions originated in the midcorpus, were 0.237 ± 0.018 cm wide, traveled along the corpus at 0.133 ± 0.024 cm/s, and had a duration of 5.9 ± 0.1 s. Antral contractions were 0.174 ± 0.032 cm wide, traveled at 0.070 ± 0.009 cm/s, and had a duration of 5.6 ± 0.7 s. During the contraction, capillary flow velocity in the corpus decreased from a basal value of 410 ± 105 to 206 ± 104 μm/s at the peak of a contraction. Five seconds after the contraction was released hyperemia was observed with the flow sease.

Original languageEnglish (US)
Pages (from-to)G524-G530
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume260
Issue number3 23-3
StatePublished - Jan 1 1991

Fingerprint

Stomach
Ischemia
Hyperemia
Transducers
Silver
Electrodes
Antral

Keywords

  • Electrical field stimulation
  • Gastric contraction propagation
  • Gastric motility
  • Gastrointestinal blood flow

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Livingston, E. H., Howard, T. J., Garrick, T. R., Passaro, E. P., & Guth, P. H. (1991). Strong gastric contractions cause mucosal ischemia. American Journal of Physiology - Gastrointestinal and Liver Physiology, 260(3 23-3), G524-G530.

Strong gastric contractions cause mucosal ischemia. / Livingston, E. H.; Howard, T. J.; Garrick, T. R.; Passaro, E. P.; Guth, P. H.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 260, No. 3 23-3, 01.01.1991, p. G524-G530.

Research output: Contribution to journalArticle

Livingston, EH, Howard, TJ, Garrick, TR, Passaro, EP & Guth, PH 1991, 'Strong gastric contractions cause mucosal ischemia', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 260, no. 3 23-3, pp. G524-G530.
Livingston, E. H. ; Howard, T. J. ; Garrick, T. R. ; Passaro, E. P. ; Guth, P. H. / Strong gastric contractions cause mucosal ischemia. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1991 ; Vol. 260, No. 3 23-3. pp. G524-G530.
@article{5ae0cb0071844192b1a4c806c50777e6,
title = "Strong gastric contractions cause mucosal ischemia",
abstract = "Contractions of a segment of bowel result in alterations of its blood flow. However, the precise temporal and spacial relationships between contractions and mucosal blood flow are unknown. Rats were fitted with strain gauge force transducers and implanted with silver wire electrodes into the muscularis externa of the stomach. In vivo microscopic observation of motility and of the gastric mucosal blood flow was performed during electrical field-stimulated contractions. Contractions originated in the midcorpus, were 0.237 ± 0.018 cm wide, traveled along the corpus at 0.133 ± 0.024 cm/s, and had a duration of 5.9 ± 0.1 s. Antral contractions were 0.174 ± 0.032 cm wide, traveled at 0.070 ± 0.009 cm/s, and had a duration of 5.6 ± 0.7 s. During the contraction, capillary flow velocity in the corpus decreased from a basal value of 410 ± 105 to 206 ± 104 μm/s at the peak of a contraction. Five seconds after the contraction was released hyperemia was observed with the flow sease.",
keywords = "Electrical field stimulation, Gastric contraction propagation, Gastric motility, Gastrointestinal blood flow",
author = "Livingston, {E. H.} and Howard, {T. J.} and Garrick, {T. R.} and Passaro, {E. P.} and Guth, {P. H.}",
year = "1991",
month = "1",
day = "1",
language = "English (US)",
volume = "260",
pages = "G524--G530",
journal = "American Journal of Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "3 23-3",

}

TY - JOUR

T1 - Strong gastric contractions cause mucosal ischemia

AU - Livingston, E. H.

AU - Howard, T. J.

AU - Garrick, T. R.

AU - Passaro, E. P.

AU - Guth, P. H.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Contractions of a segment of bowel result in alterations of its blood flow. However, the precise temporal and spacial relationships between contractions and mucosal blood flow are unknown. Rats were fitted with strain gauge force transducers and implanted with silver wire electrodes into the muscularis externa of the stomach. In vivo microscopic observation of motility and of the gastric mucosal blood flow was performed during electrical field-stimulated contractions. Contractions originated in the midcorpus, were 0.237 ± 0.018 cm wide, traveled along the corpus at 0.133 ± 0.024 cm/s, and had a duration of 5.9 ± 0.1 s. Antral contractions were 0.174 ± 0.032 cm wide, traveled at 0.070 ± 0.009 cm/s, and had a duration of 5.6 ± 0.7 s. During the contraction, capillary flow velocity in the corpus decreased from a basal value of 410 ± 105 to 206 ± 104 μm/s at the peak of a contraction. Five seconds after the contraction was released hyperemia was observed with the flow sease.

AB - Contractions of a segment of bowel result in alterations of its blood flow. However, the precise temporal and spacial relationships between contractions and mucosal blood flow are unknown. Rats were fitted with strain gauge force transducers and implanted with silver wire electrodes into the muscularis externa of the stomach. In vivo microscopic observation of motility and of the gastric mucosal blood flow was performed during electrical field-stimulated contractions. Contractions originated in the midcorpus, were 0.237 ± 0.018 cm wide, traveled along the corpus at 0.133 ± 0.024 cm/s, and had a duration of 5.9 ± 0.1 s. Antral contractions were 0.174 ± 0.032 cm wide, traveled at 0.070 ± 0.009 cm/s, and had a duration of 5.6 ± 0.7 s. During the contraction, capillary flow velocity in the corpus decreased from a basal value of 410 ± 105 to 206 ± 104 μm/s at the peak of a contraction. Five seconds after the contraction was released hyperemia was observed with the flow sease.

KW - Electrical field stimulation

KW - Gastric contraction propagation

KW - Gastric motility

KW - Gastrointestinal blood flow

UR - http://www.scopus.com/inward/record.url?scp=0025903651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025903651&partnerID=8YFLogxK

M3 - Article

C2 - 2003615

AN - SCOPUS:0025903651

VL - 260

SP - G524-G530

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0193-1857

IS - 3 23-3

ER -