Strophanthidin-sensitive sodium fluxes in metabolically poisoned frog skeletal muscle

Brian G. Kennedy, Paul De Weer

Research output: Contribution to journalArticle

11 Scopus citations


Strophanthidin-sensitive and insensitive unidirectional fluxes of Na were measured in frog sartorius muscles whose internal Na levels were elevated by overnight storage in the cold. ATP levels were lowered, and ADP levels raised, by metabolic poisoning with either 2,4-dinitrofluorobenzene or iodoacetamide. Strophanthidin- sensitive Na efflux and influx both increased after poisoning, while strophanthidin-insensitive fluxes did not. The increase in efflux did not require the presence of external K but was greatly attenuated when Li replaced Na as the major external cation. Membrane potential was not markedly altered by 2,4- dinitrofluorobenzene. These observations indicate that the sodium pump of frog skeletal muscle resembles that of squid giant axon and human erythrocyte in its ability to catalyze Na-Na exchange to an extent determined by intracellular ATP/ ADP levels.

Original languageEnglish (US)
Pages (from-to)405-420
Number of pages16
JournalJournal of General Physiology
Issue number4
StatePublished - Oct 1 1976

ASJC Scopus subject areas

  • Physiology

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