Structural analyses of fibrinogen amyloid fibrils

Louise C. Serpell, Merrill Benson, Juris J. Liepnieks, Paul E. Fraser

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Hereditary fibrinogen amyloidosis is characterized by deposition of amyloid fibrils in renal glomeruli. The subunit protein of the amyloid fibrils is a proteolytic fragment of the fibrinogen Aα-chain. To investigate the structure of fibrinogen amyloid, fibrils were extracted from the tissues of a patient and studied by X-ray fiber diffraction and electron microscopy. We have carried out a full structural characterization of amyloid fibrils taken from disease tissue. These studies revealed that ex vivo fibrinogen amyloid fibrils have a cross-β structure similar to other chemical types of amyloid fibrils.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalAmyloid
Volume14
Issue number3
DOIs
StatePublished - 2007

Fingerprint

Amyloid
Fibrinogen
Familial Amyloidosis
Protein Subunits
X-Ray Diffraction
Electron Microscopy
Kidney

Keywords

  • Amyloid
  • Electron microscopy
  • Fiber diffraction
  • Fibrinogen
  • Protein structure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Serpell, L. C., Benson, M., Liepnieks, J. J., & Fraser, P. E. (2007). Structural analyses of fibrinogen amyloid fibrils. Amyloid, 14(3), 199-203. https://doi.org/10.1080/13506120701461111

Structural analyses of fibrinogen amyloid fibrils. / Serpell, Louise C.; Benson, Merrill; Liepnieks, Juris J.; Fraser, Paul E.

In: Amyloid, Vol. 14, No. 3, 2007, p. 199-203.

Research output: Contribution to journalArticle

Serpell, LC, Benson, M, Liepnieks, JJ & Fraser, PE 2007, 'Structural analyses of fibrinogen amyloid fibrils', Amyloid, vol. 14, no. 3, pp. 199-203. https://doi.org/10.1080/13506120701461111
Serpell, Louise C. ; Benson, Merrill ; Liepnieks, Juris J. ; Fraser, Paul E. / Structural analyses of fibrinogen amyloid fibrils. In: Amyloid. 2007 ; Vol. 14, No. 3. pp. 199-203.
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