Structural basis of multimer-mediated mayhem

Kajal V. Sitwala, Jay Hess

Research output: Contribution to journalArticle

Abstract

Oligomerization of AML1-ETO contributes to leukemogenesis through obscure mechanisms. In this issue of Cancer Cell, Bushweller and colleagues show the crystal structure of the ETO NHR2 domain to be a tetramer. Tetramer formation is important for maturation arrest and self-renewal, and gene expression is altered in the absence of self-association. Loss of oligomer formation disrupts interactions between AML1-ETO and members of the ETO corepressor family, but not other corepressor molecules posited to be important for leukemogenesis. The findings clarify the role of oligomer formation in AML1-ETO function and suggest a possible therapeutic strategy of targeting ETO-corepressor interactions.

Original languageEnglish (US)
Pages (from-to)241-242
Number of pages2
JournalCancer Cell
Volume9
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

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Co-Repressor Proteins
Gene Expression
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Structural basis of multimer-mediated mayhem. / Sitwala, Kajal V.; Hess, Jay.

In: Cancer Cell, Vol. 9, No. 4, 04.2006, p. 241-242.

Research output: Contribution to journalArticle

Sitwala, Kajal V. ; Hess, Jay. / Structural basis of multimer-mediated mayhem. In: Cancer Cell. 2006 ; Vol. 9, No. 4. pp. 241-242.
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