Structural changes in the proximal tubule of kidneys from hypophysectomized rats

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The present study was undertaken to determine what structural changes hypophysectomy would cause in the rat kidney. Proximal convoluted tubule cells from hypophysectomized rats were smaller and their length was decreased when compared to kidneys from control animals of approximately the same weight as the hypophysectomized animals. Electron microscopic observation of the kidneys from the hypophysectomized rats revealed that the cells of the proximal convoluted tubules had (1) an increase in size and number of dense bodies (type II cytosome); (2) a decrease in smooth endoplasmic reticulum (SER); (3) a decrease in basilar infoldings; (4) an increase in the frequency of mitochondria cristae aligned in their longitudinal axis and (5) a change in the character of the profiles of smooth endoplasmic reticulum (SER) related to microbodies (type I cytosome) from a vesicular to tubular arrangement. The changes noted in the cells of the proximal convoluted tubules of hypophysectomized rats were similar to previously described changes observed in tubular atrophy.

Original languageEnglish (US)
Pages (from-to)265-277
Number of pages13
JournalThe Anatomical Record
Issue number2
StatePublished - Oct 1972


ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)

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