Structural genomics of protein phosphatases

Steven C. Almo, Jeffrey B. Bonanno, J. Michael Sauder, Spencer Emtage, Teresa P. Dilorenzo, Vladimir Malashkevich, Steven R. Wasserman, S. Swaminathan, Subramaniam Eswaramoorthy, Rakhi Agarwal, Desigan Kumaran, Mahendra Madegowda, Sugadev Ragumani, Yury Patskovsky, Johnjeff Alvarado, Udupi A. Ramagopal, Joana Faber-Barata, Mark R. Chance, Andrej Sali, Andras FiserZhong Yin Zhang, David S. Lawrence, Stephen K. Burley

Research output: Contribution to journalReview article

99 Scopus citations

Abstract

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

Original languageEnglish (US)
Pages (from-to)121-140
Number of pages20
JournalJournal of Structural and Functional Genomics
Volume8
Issue number2-3
DOIs
StatePublished - Sep 2007

Keywords

  • NYSGXRC
  • Phosphatase
  • Structural genomics
  • X-ray crystallography

ASJC Scopus subject areas

  • Genetics
  • Structural Biology
  • Biochemistry

Fingerprint Dive into the research topics of 'Structural genomics of protein phosphatases'. Together they form a unique fingerprint.

  • Cite this

    Almo, S. C., Bonanno, J. B., Sauder, J. M., Emtage, S., Dilorenzo, T. P., Malashkevich, V., Wasserman, S. R., Swaminathan, S., Eswaramoorthy, S., Agarwal, R., Kumaran, D., Madegowda, M., Ragumani, S., Patskovsky, Y., Alvarado, J., Ramagopal, U. A., Faber-Barata, J., Chance, M. R., Sali, A., ... Burley, S. K. (2007). Structural genomics of protein phosphatases. Journal of Structural and Functional Genomics, 8(2-3), 121-140. https://doi.org/10.1007/s10969-007-9036-1