Structure activity relations of some indolealkylamines in comparison to phenethylamines on motor activity and acquisition of avoidance behavior

Michael R. Vasko, Michael P. Lutz, Edward F. Domino

Research output: Contribution to journalArticle

3 Scopus citations


The structure-activity relationships (SAR) of various known hallucinogenic and nonhallucinogenic indolealkylamine and phenethylamine derivatives were compared on two different behaviors: mouse locomotor activity and acquisition of one-way avoidance behavior in the rat. Certain parallels were observed between the two classes of compounds. α-Methyl substituted derivatives of the indoles and phenethylamines increased dramatically psychomotor stimulant effects. Acquisition of one-way avoidance behavior was reduced by the more potent hallucinogens and psychomotor stimulants of both classes. Pargyline pretreatment enhanced the psychomotor stimulant effects of all of the compounds tested except 5-hydroxy-tryptamine (5-HT), d-amphetamine, mescaline and lysergic acid diethylamide (LSD-25).

Original languageEnglish (US)
Pages (from-to)49-58
Number of pages10
Issue number1
StatePublished - Mar 1 1974



  • Hallucinogens
  • Indolealkylamines
  • LSD-25
  • Locomotor Activity
  • Monoamine Oxidase Inhibitor
  • One-Way Avoidance Behavior
  • Phenethylamines

ASJC Scopus subject areas

  • Pharmacology

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