Structure-activity relationships of novel hematoregulatory peptides

Pradip K. Bhatnagar, Erik K. Agner, Doreen Alberts, Bente E. Arbo, James F. Callahan, Allan S. Cuthbertson, Steinar J. Engelsen, Hege Fjerdingstad, Michael Hartmann, Dirk Heerding, Johann Hiebl, William F. Huffman, Mette Hysben, Andrew G. King, Peter Kremminger, Chet Kwon, Steve LoCastro, Dagfinn Løvhaug, Louis M. Pelus, Steve PettewayJoanne S. Takata

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Hematopoiesis is a lifelong cell renewal process regulated by a family of lineage specific hematopoietic growth factors. Several hematopoietic growth factors such as G-CSF, GM-CSF, and M-CSF have been clinically evaluated for enhancement of host defense in normal and immunocompromised patients and for the treatment of infectious diseases. This paper reports the structure-activity relationships of low molecular weight hematoregulatory peptides based on a nonapeptide (1, SK and F 107647). Like the macromolecular growth factors, these peptides modulate host defense. A molecular target for this class of compounds has not yet been identified. However, the structure- activity relationships established by this study implicate a very specific molecular recognition event that is pivotal for the biological activities of 1 and its analogues.

Original languageEnglish (US)
Pages (from-to)3814-3819
Number of pages6
JournalJournal of Medicinal Chemistry
Volume39
Issue number19
DOIs
StatePublished - Sep 13 1996

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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    Bhatnagar, P. K., Agner, E. K., Alberts, D., Arbo, B. E., Callahan, J. F., Cuthbertson, A. S., Engelsen, S. J., Fjerdingstad, H., Hartmann, M., Heerding, D., Hiebl, J., Huffman, W. F., Hysben, M., King, A. G., Kremminger, P., Kwon, C., LoCastro, S., Løvhaug, D., Pelus, L. M., ... Takata, J. S. (1996). Structure-activity relationships of novel hematoregulatory peptides. Journal of Medicinal Chemistry, 39(19), 3814-3819. https://doi.org/10.1021/jm960099d