Studies on an animal model of alcoholism.

T. K. Li, L. Lumeng, W. J. McBride, M. B. Waller, J. M. Murphy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Past and ongoing studies indicate that the selectively bred P line of rats satisfies virtually all the suggested criteria for an animal model of alcoholism. They attain pharmacologically active levels of BAC and develop tolerance and physical dependence with voluntary oral ethanol ingestion, while in the free-feeding state. Ethanol is positively reinforcing to the P rats and consumption appears to be directed by the post-ingestive, pharmacological effects of ethanol, as revealed by the intragastric self-administration studies. Some interesting differences between the P and the NP lines have been uncovered. They differ in the content of serotonin in several brain regions and they respond differently to ethanol. The P rats develop acute tolerance to sedative-hypnotic doses of ethanol more rapidly than do the NP rats, and they exhibit stimulation with low doses of ethanol. These differences suggest hypotheses on mechanisms underlying alcohol-seeking behavior which can now be tested experimentally. It should be emphasized, however, that the described findings are the product of but a single genetic experiment. Clearly, replication is needed, and we are currently doing this, using a better defined, heterogeneous stock of rats. This one experiment, however, has demonstrated the feasibility of developing animal models of alcoholism and offers hope that the genetic and biological basis of alcohol-seeking behavior can be explored in the laboratory. The screening and testing of pharmacological agents able to deter alcohol-seeking behavior is an obvious practical application of this model.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalNIDA research monograph
Volume66
StatePublished - 1986
Externally publishedYes

Fingerprint

Alcoholism
Ethanol
Animal Models
Alcohols
Hope
Pharmacology
Self Administration
Hypnotics and Sedatives
Serotonin
Eating
Brain

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Li, T. K., Lumeng, L., McBride, W. J., Waller, M. B., & Murphy, J. M. (1986). Studies on an animal model of alcoholism. NIDA research monograph, 66, 41-49.

Studies on an animal model of alcoholism. / Li, T. K.; Lumeng, L.; McBride, W. J.; Waller, M. B.; Murphy, J. M.

In: NIDA research monograph, Vol. 66, 1986, p. 41-49.

Research output: Contribution to journalArticle

Li, TK, Lumeng, L, McBride, WJ, Waller, MB & Murphy, JM 1986, 'Studies on an animal model of alcoholism.', NIDA research monograph, vol. 66, pp. 41-49.
Li TK, Lumeng L, McBride WJ, Waller MB, Murphy JM. Studies on an animal model of alcoholism. NIDA research monograph. 1986;66:41-49.
Li, T. K. ; Lumeng, L. ; McBride, W. J. ; Waller, M. B. ; Murphy, J. M. / Studies on an animal model of alcoholism. In: NIDA research monograph. 1986 ; Vol. 66. pp. 41-49.
@article{7ea85cf0f48b4188acfd309967873d63,
title = "Studies on an animal model of alcoholism.",
abstract = "Past and ongoing studies indicate that the selectively bred P line of rats satisfies virtually all the suggested criteria for an animal model of alcoholism. They attain pharmacologically active levels of BAC and develop tolerance and physical dependence with voluntary oral ethanol ingestion, while in the free-feeding state. Ethanol is positively reinforcing to the P rats and consumption appears to be directed by the post-ingestive, pharmacological effects of ethanol, as revealed by the intragastric self-administration studies. Some interesting differences between the P and the NP lines have been uncovered. They differ in the content of serotonin in several brain regions and they respond differently to ethanol. The P rats develop acute tolerance to sedative-hypnotic doses of ethanol more rapidly than do the NP rats, and they exhibit stimulation with low doses of ethanol. These differences suggest hypotheses on mechanisms underlying alcohol-seeking behavior which can now be tested experimentally. It should be emphasized, however, that the described findings are the product of but a single genetic experiment. Clearly, replication is needed, and we are currently doing this, using a better defined, heterogeneous stock of rats. This one experiment, however, has demonstrated the feasibility of developing animal models of alcoholism and offers hope that the genetic and biological basis of alcohol-seeking behavior can be explored in the laboratory. The screening and testing of pharmacological agents able to deter alcohol-seeking behavior is an obvious practical application of this model.",
author = "Li, {T. K.} and L. Lumeng and McBride, {W. J.} and Waller, {M. B.} and Murphy, {J. M.}",
year = "1986",
language = "English",
volume = "66",
pages = "41--49",
journal = "NIDA Research Monograph Series",
issn = "1046-9516",
publisher = "National Institute on Drug Abuse",

}

TY - JOUR

T1 - Studies on an animal model of alcoholism.

AU - Li, T. K.

AU - Lumeng, L.

AU - McBride, W. J.

AU - Waller, M. B.

AU - Murphy, J. M.

PY - 1986

Y1 - 1986

N2 - Past and ongoing studies indicate that the selectively bred P line of rats satisfies virtually all the suggested criteria for an animal model of alcoholism. They attain pharmacologically active levels of BAC and develop tolerance and physical dependence with voluntary oral ethanol ingestion, while in the free-feeding state. Ethanol is positively reinforcing to the P rats and consumption appears to be directed by the post-ingestive, pharmacological effects of ethanol, as revealed by the intragastric self-administration studies. Some interesting differences between the P and the NP lines have been uncovered. They differ in the content of serotonin in several brain regions and they respond differently to ethanol. The P rats develop acute tolerance to sedative-hypnotic doses of ethanol more rapidly than do the NP rats, and they exhibit stimulation with low doses of ethanol. These differences suggest hypotheses on mechanisms underlying alcohol-seeking behavior which can now be tested experimentally. It should be emphasized, however, that the described findings are the product of but a single genetic experiment. Clearly, replication is needed, and we are currently doing this, using a better defined, heterogeneous stock of rats. This one experiment, however, has demonstrated the feasibility of developing animal models of alcoholism and offers hope that the genetic and biological basis of alcohol-seeking behavior can be explored in the laboratory. The screening and testing of pharmacological agents able to deter alcohol-seeking behavior is an obvious practical application of this model.

AB - Past and ongoing studies indicate that the selectively bred P line of rats satisfies virtually all the suggested criteria for an animal model of alcoholism. They attain pharmacologically active levels of BAC and develop tolerance and physical dependence with voluntary oral ethanol ingestion, while in the free-feeding state. Ethanol is positively reinforcing to the P rats and consumption appears to be directed by the post-ingestive, pharmacological effects of ethanol, as revealed by the intragastric self-administration studies. Some interesting differences between the P and the NP lines have been uncovered. They differ in the content of serotonin in several brain regions and they respond differently to ethanol. The P rats develop acute tolerance to sedative-hypnotic doses of ethanol more rapidly than do the NP rats, and they exhibit stimulation with low doses of ethanol. These differences suggest hypotheses on mechanisms underlying alcohol-seeking behavior which can now be tested experimentally. It should be emphasized, however, that the described findings are the product of but a single genetic experiment. Clearly, replication is needed, and we are currently doing this, using a better defined, heterogeneous stock of rats. This one experiment, however, has demonstrated the feasibility of developing animal models of alcoholism and offers hope that the genetic and biological basis of alcohol-seeking behavior can be explored in the laboratory. The screening and testing of pharmacological agents able to deter alcohol-seeking behavior is an obvious practical application of this model.

UR - http://www.scopus.com/inward/record.url?scp=0022823913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022823913&partnerID=8YFLogxK

M3 - Article

VL - 66

SP - 41

EP - 49

JO - NIDA Research Monograph Series

JF - NIDA Research Monograph Series

SN - 1046-9516

ER -