Studies with aprindine

Douglas P. Zipes, Victor Elharrar, Robert F. Gilmour, James J. Heger, Eric N. Prystowsky

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Aprindine is a very effective antiarrhythmic agent with a narrow therapeutic-toxic ratio. It has been used successfully in treating patients who have both supraventricular and ventricular tachyarrhythmias. Aprindine slows conduction in all cardiac fibers and suppresses digitalis-induced after-depolarizations. Voltage-clamp studies indicate that aprindine, in higher doses, suppresses the slow inward current in frog atria. In the dog subjected to coronary artery occlusion, aprindine may be arrhythmogenic, antiarrhythmic, or have no effect on the development of arrhythmias, depending on the temporal relationship between time of administration and time of occlusion.

Original languageEnglish (US)
Pages (from-to)1055-1062
Number of pages8
JournalAmerican Heart Journal
Volume100
Issue number6 PART 2
DOIs
StatePublished - Dec 1980

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Zipes, D. P., Elharrar, V., Gilmour, R. F., Heger, J. J., & Prystowsky, E. N. (1980). Studies with aprindine. American Heart Journal, 100(6 PART 2), 1055-1062. https://doi.org/10.1016/0002-8703(80)90213-6