Study of blood flow impact on growth of thrombi using a multiscale model

Zhiliang Xu, Nan Chen, Shawn C. Shadden, Jerrold E. Marsden, Malgorzata Kamocka, Elliot Rosen, Mark Alber

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

An extended multiscale model is introduced for studying the formation of platelet thrombi in blood vessels. The model describes the interplay between viscous, incompressible blood plasma, activated and non-activated platelets, as well as other blood cells, activating chemicals, fibrinogen and vessel walls. The macroscale dynamics of the blood flow is represented by the continuous submodel in the form of the Navier-Stokes equations. The microscale cell-cell interactions are described by the stochastic Cellular Potts Model (CPM). Simulations indicate that increase in flow rates leads to greater structural heterogeneity of the clot. As heterogeneous structural domains within the clot affect thrombus stability, understanding the factors influencing thrombus structure is of significant biomedical importance.

Original languageEnglish
Pages (from-to)769-779
Number of pages11
JournalSoft Matter
Volume5
Issue number4
DOIs
StatePublished - 2009

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multiscale models
blood flow
platelets
Blood
Platelets
blood plasma
fibrinogen
blood cells
blood vessels
cells
Potts model
microbalances
Navier-Stokes equation
vessels
flow velocity
Blood vessels
Fibrinogen
Navier Stokes equations
Cells
Flow rate

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Study of blood flow impact on growth of thrombi using a multiscale model. / Xu, Zhiliang; Chen, Nan; Shadden, Shawn C.; Marsden, Jerrold E.; Kamocka, Malgorzata; Rosen, Elliot; Alber, Mark.

In: Soft Matter, Vol. 5, No. 4, 2009, p. 769-779.

Research output: Contribution to journalArticle

Xu, Z, Chen, N, Shadden, SC, Marsden, JE, Kamocka, M, Rosen, E & Alber, M 2009, 'Study of blood flow impact on growth of thrombi using a multiscale model', Soft Matter, vol. 5, no. 4, pp. 769-779. https://doi.org/10.1039/b812429a
Xu, Zhiliang ; Chen, Nan ; Shadden, Shawn C. ; Marsden, Jerrold E. ; Kamocka, Malgorzata ; Rosen, Elliot ; Alber, Mark. / Study of blood flow impact on growth of thrombi using a multiscale model. In: Soft Matter. 2009 ; Vol. 5, No. 4. pp. 769-779.
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