Study of changes of local cerebral blood flow in administration of vasoactive agents in microdialysis

O. S. Medvedev, E. Yu Bychkova, S. A. Volchikhina, Dmitry Zaretsky, A. N. Murashev, M. V. Nikitina

Research output: Contribution to journalArticle

Abstract

The authors suggest the construction of a cannula for microdialysis combined with a light guide of a laser doppler flowmeter. Such a design allows monitoring of blood flow intensity in the environment of the microdialyzer. An advantage of local administration of vasoactive agents is that they cause no effect on systemic arterial pressure. When administered locally, sodium nitroprusside increased whereas the inhibitor NO-synthase reduced blood flow intensity. No changes were detected in the local blood flow in administration of phenylephrine and nitroglycerin through the dialyzer. Tetrodoxin insignificantly reduced the blood flow. The existence of a diffusion barrier for some agents as well as the long period of time needed for attaining the state of equilibrium after beginning perfusion of the solution containing the agent under test is among the disadvantages of local administration.

Original languageEnglish (US)
Pages (from-to)22-23
Number of pages2
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume62
Issue number1
StatePublished - 1999
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Microdialysis
Blood
Flowmeters
Diffusion barriers
Nitroglycerin
Nitroprusside
Phenylephrine
Nitric Oxide Synthase
Arterial Pressure
Lasers
Perfusion
Light
Monitoring

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Medvedev, O. S., Bychkova, E. Y., Volchikhina, S. A., Zaretsky, D., Murashev, A. N., & Nikitina, M. V. (1999). Study of changes of local cerebral blood flow in administration of vasoactive agents in microdialysis. Eksperimental'naya i Klinicheskaya Farmakologiya, 62(1), 22-23.

Study of changes of local cerebral blood flow in administration of vasoactive agents in microdialysis. / Medvedev, O. S.; Bychkova, E. Yu; Volchikhina, S. A.; Zaretsky, Dmitry; Murashev, A. N.; Nikitina, M. V.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 62, No. 1, 1999, p. 22-23.

Research output: Contribution to journalArticle

Medvedev, OS, Bychkova, EY, Volchikhina, SA, Zaretsky, D, Murashev, AN & Nikitina, MV 1999, 'Study of changes of local cerebral blood flow in administration of vasoactive agents in microdialysis', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 62, no. 1, pp. 22-23.
Medvedev, O. S. ; Bychkova, E. Yu ; Volchikhina, S. A. ; Zaretsky, Dmitry ; Murashev, A. N. ; Nikitina, M. V. / Study of changes of local cerebral blood flow in administration of vasoactive agents in microdialysis. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 1999 ; Vol. 62, No. 1. pp. 22-23.
@article{d77fe1dadcea44ac9b8b2605e28e0e10,
title = "Study of changes of local cerebral blood flow in administration of vasoactive agents in microdialysis",
abstract = "The authors suggest the construction of a cannula for microdialysis combined with a light guide of a laser doppler flowmeter. Such a design allows monitoring of blood flow intensity in the environment of the microdialyzer. An advantage of local administration of vasoactive agents is that they cause no effect on systemic arterial pressure. When administered locally, sodium nitroprusside increased whereas the inhibitor NO-synthase reduced blood flow intensity. No changes were detected in the local blood flow in administration of phenylephrine and nitroglycerin through the dialyzer. Tetrodoxin insignificantly reduced the blood flow. The existence of a diffusion barrier for some agents as well as the long period of time needed for attaining the state of equilibrium after beginning perfusion of the solution containing the agent under test is among the disadvantages of local administration.",
author = "Medvedev, {O. S.} and Bychkova, {E. Yu} and Volchikhina, {S. A.} and Dmitry Zaretsky and Murashev, {A. N.} and Nikitina, {M. V.}",
year = "1999",
language = "English (US)",
volume = "62",
pages = "22--23",
journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",
issn = "0869-2092",
publisher = "Izdatelstvo Meditsina",
number = "1",

}

TY - JOUR

T1 - Study of changes of local cerebral blood flow in administration of vasoactive agents in microdialysis

AU - Medvedev, O. S.

AU - Bychkova, E. Yu

AU - Volchikhina, S. A.

AU - Zaretsky, Dmitry

AU - Murashev, A. N.

AU - Nikitina, M. V.

PY - 1999

Y1 - 1999

N2 - The authors suggest the construction of a cannula for microdialysis combined with a light guide of a laser doppler flowmeter. Such a design allows monitoring of blood flow intensity in the environment of the microdialyzer. An advantage of local administration of vasoactive agents is that they cause no effect on systemic arterial pressure. When administered locally, sodium nitroprusside increased whereas the inhibitor NO-synthase reduced blood flow intensity. No changes were detected in the local blood flow in administration of phenylephrine and nitroglycerin through the dialyzer. Tetrodoxin insignificantly reduced the blood flow. The existence of a diffusion barrier for some agents as well as the long period of time needed for attaining the state of equilibrium after beginning perfusion of the solution containing the agent under test is among the disadvantages of local administration.

AB - The authors suggest the construction of a cannula for microdialysis combined with a light guide of a laser doppler flowmeter. Such a design allows monitoring of blood flow intensity in the environment of the microdialyzer. An advantage of local administration of vasoactive agents is that they cause no effect on systemic arterial pressure. When administered locally, sodium nitroprusside increased whereas the inhibitor NO-synthase reduced blood flow intensity. No changes were detected in the local blood flow in administration of phenylephrine and nitroglycerin through the dialyzer. Tetrodoxin insignificantly reduced the blood flow. The existence of a diffusion barrier for some agents as well as the long period of time needed for attaining the state of equilibrium after beginning perfusion of the solution containing the agent under test is among the disadvantages of local administration.

UR - http://www.scopus.com/inward/record.url?scp=0043235230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0043235230&partnerID=8YFLogxK

M3 - Article

C2 - 10198759

AN - SCOPUS:0043235230

VL - 62

SP - 22

EP - 23

JO - Eksperimental'naya i Klinicheskaya Farmakologiya

JF - Eksperimental'naya i Klinicheskaya Farmakologiya

SN - 0869-2092

IS - 1

ER -