Study of epicardial activation in low voltage gradient regions during a defibrillation shock with panoramic optical mapping

R. Province, S. F. Lin, M. Brooks, M. Fishler, D. Echt

Research output: Contribution to journalConference article


We have developed a new optical imaging system from which we can obtain time sequences of images representing the transmembrane potentials across the entire epicardial surface of the isolated rabbit heart. We processed these images to obtain quantitative timing and spatial information about the activation wavefronts immediately prior to (PrSA), during, and immediately after (PoSA) a defibrillation (DF) shock. We hypothesize that the spatiotemporal dynamics of the wavefronts at the time of a DF shock directly influence it's outcome. We delivered threshold level shocks with voltages that were not significantly different for successes (S) and failures (F). But a significantly higher percentage area of the low voltage gradient region (LVGR) was activated by PrSA in S compared to F episodes, while there was no significant difference in the extent of PrSA in the epicardium as a whole. We conclude that the LVGR is a critical region where the extent of tissue activation is significant in determining the outcome of DF.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalComputers in Cardiology
StatePublished - Dec 1 1997
EventProceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden
Duration: Sep 7 1997Sep 10 1997


ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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