Study of Sonic hedgehog signaling pathway related molecules in gastric carcinoma

Xiao Li Ma, Hai Ji Sun, Yun Shan Wang, Shu Hong Huang, Jing Wu Xie, Hong Wei Zhang

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Aim: To study the expression of Sonic hedgehog pathway-related molecules, Sonic hedgehog (Shh) and Gli1 in gastric carcinoma. Methods: Expression of Shh in 56 gastric specimens including non-cancerous gastric tissues, gastric adenocarcinoma, gastric squamous cell carcinoma was detected by RT-PCR, in situ hybridization and immunohistochemistry. Expression of Gli1 was observed by in situ hybridization. Results: The positive rate of Shh and Gli1 expression wa s 0.0%, 0.0% in non-cancerous gastric tissues while it was 66.7%, 57.8% respectively in gastric adenocarcinoma, and 100%, 100% respectively in gastric squamous cell carcinoma. There was a significant difference between the non-cancerous gastric tissues and gastric carcinoma (P < 0.05). Elevated expression of Shh and Gli1 in gastric tubular adenocarcinoma was associated with poorly differentiated tumors while the expression was absent in gastric mucinous adenocarcinoma. Conclusion: The elevated exp ression of Shh and Gli1 in gastric adenocarcinoma and gastric squamous cell carcinoma shows the involvement of activated Shh signaling in the cellular proliferation of gastric carcinogenesis. It suggests Shh signaling gene may be a new and good target gene for gastric tumor diagnosis and therapy.

Original languageEnglish (US)
Pages (from-to)3965-3969
Number of pages5
JournalWorld Journal of Gastroenterology
Volume12
Issue number25
DOIs
StatePublished - Jul 7 2006
Externally publishedYes

Keywords

  • Gastric adenocarcinoma
  • Gastric carcinoma
  • Gastric squamous cell carcinoma
  • Gli1
  • Sonic hedgehog
  • Sonic hedgehog pathway

ASJC Scopus subject areas

  • Gastroenterology

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