Studying alcohol elimination using the alcohol clamp method

Vijay A. Ramchandani, Sean O'Connor

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Researchers studying alcohol absorption and metabolism in humans have been aided by the alcohol clamp method, in which alcohol is administered intravenously, allowing study participants to achieve and maintain a target breath alcohol concentration (BrAC) for an extended period of time. This tool minimizes the variability in BrACs that occurs after alcohol consumption by administering alcohol at a dose and rate that is computed for each person individually. The alcohol clamp can be used to evaluate several influences on alcohol elimination, including gender, ethnicity, genetic variations in alcohol-metabolizing enzymes, and food consumption.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalAlcohol Research and Health
Volume29
Issue number4
StatePublished - Dec 1 2006

Keywords

  • Alcohol absorption
  • Alcohol clamp method
  • Alcohol elimination
  • Alcohol elimination rate (AER)
  • Breath alcohol concentration (BrAC)
  • Ethanol metabolism
  • Intravenous infusion
  • Michaelis-Menten kinetics
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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