Subacute sclerosing panencephalitis manifesting as viral retinitis: Clinical and histopathologic findings

D. W. Park, H. C. Boldt, S. J. Massicotte, E. E U Akang, Karen Roos, A. Bodnar, J. Pless, Bernardino Ghetti, Robert Pascuzzi

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To describe the clinical and histopathologic features of a patient with viral retinitis secondary to subacute sclerosing panencephalitis. RESULTS: The patient was a human immunodeficiency virus- negative intravenous drug abuser with an acute retinitis that later progressed to encephalitis despite aggressive treatment for possible vital, protozoal, bacterial, and rickettsial infections. The patient had many of the characteristic findings of subacute sclerosing panencephalitis, including a history of measles in early childhood, myoclonus, periodic complexes on electroencephalographic testing, persistently elevated serum and cerebrospinal fluid antimeasles immunoglobulin G (IgG) titers, and a cerebrospinal fluid oligoclonal IgG gammopathy. Ultrastructural examination demonstrated numerous filamentous microtubular intranuclear viral inclusions in the nuclear layers of the retina consistent with the measles virus. This case is unusual in that our patient developed subacute sclerosing panencephalitis later in life and because there was an 8-year period between presumed viral infections in the two eyes. CONCLUSIONS: An acute retinitis in an intravenous drug abuser is not always caused by human immunodeficiency virus-related infections; not all viral retinitis responds to therapy; and mortality as well as the usual morbidity may be associated with viral retinitis. One might consider the diagnosis of subacute sclerosing panencephalitis in a young person with an acute retinitis with little or no vitreal inflammation and lack of response to anticytomegalovirus and antitoxoplasmosis therapy.

Original languageEnglish (US)
Pages (from-to)533-542
Number of pages10
JournalAmerican Journal of Ophthalmology
Volume123
Issue number4
StatePublished - 1997
Externally publishedYes

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Subacute Sclerosing Panencephalitis
Retinitis
Virus Diseases
Drug Users
Cerebrospinal Fluid
Immunoglobulin G
HIV
Oligoclonal Bands
Intranuclear Inclusion Bodies
Measles virus
Myoclonus
Measles
Encephalitis
Bacterial Infections
Retina
Therapeutics
Inflammation
Morbidity
Mortality
Serum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Subacute sclerosing panencephalitis manifesting as viral retinitis : Clinical and histopathologic findings. / Park, D. W.; Boldt, H. C.; Massicotte, S. J.; Akang, E. E U; Roos, Karen; Bodnar, A.; Pless, J.; Ghetti, Bernardino; Pascuzzi, Robert.

In: American Journal of Ophthalmology, Vol. 123, No. 4, 1997, p. 533-542.

Research output: Contribution to journalArticle

Park, D. W. ; Boldt, H. C. ; Massicotte, S. J. ; Akang, E. E U ; Roos, Karen ; Bodnar, A. ; Pless, J. ; Ghetti, Bernardino ; Pascuzzi, Robert. / Subacute sclerosing panencephalitis manifesting as viral retinitis : Clinical and histopathologic findings. In: American Journal of Ophthalmology. 1997 ; Vol. 123, No. 4. pp. 533-542.
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