Subcut

Anisiia Doytchinova, Jheel Patel, Shengmei Zhou, Lan S. Chen, Hongbo Lin, Changyu Shen, Thomas H. Everett, Shien Fong Lin, Peng Sheng Chen

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background Stellate ganglion nerve activity (SGNA) is important in ventricular arrhythmogenesis. However, because thoracotomy is needed to access the stellate ganglion, it is difficult to use SGNA for risk stratification. Objective The purpose of this study was to test the hypothesis that subcutaneous nerve activity (SCNA) in canines can be used to estimate SGNA and predict ventricular arrhythmia. Methods We implanted radiotransmitters to continuously monitor left stellate ganglion and subcutaneous electrical activities in 7 ambulatory dogs with myocardial infarction, complete heart block, and nerve growth factor infusion to the left stellate ganglion. Results Spontaneous ventricular tachycardia (VT) or ventricular fibrillation (VF) was documented in each dog. SCNA preceded a combined 61 episodes of VT and VF, 61 frequent bigeminy or couplets, and 61 premature ventricular contractions within 15 seconds in 70%, 59%, and 61% of arrhythmias, respectively. Similar incidence of 75%, 69%, and 62% was noted for SGNA. Progressive increase in SCNA [48.9 (95% confidence interval [CI] 39.3-58.5) vs 61.8 (95% CI 45.9-77.6) vs 75.1 (95% CI 57.5-92.7) mV-s] and SGNA [48.6 (95% CI 40.9-56.3) vs 58.5 (95% CI 47.5-69.4) vs 69.0 (95% CI 53.8-84.2) mV-s] integrated over 20-second intervals was demonstrated 60 seconds, 40 seconds, and 20 seconds before VT/VF (P <.05), respectively. The Pearson correlation coefficient for integrated SCNA and SGNA was 0.73 ± 0.18 (P <.0001 for all dogs, n = 5). Both SCNA and SGNA exhibited circadian variation. Conclusion SCNA can be used as an estimate of SGNA to predict susceptibility to VT and VF in a canine model of ventricular arrhythmia and sudden cardiac death.

Original languageEnglish (US)
Pages (from-to)612-620
Number of pages9
JournalHeart Rhythm
Volume12
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Atrioventricular block
  • Autonomic nervous system
  • Myocardial infarction
  • Sudden cardiac death
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Doytchinova, A., Patel, J., Zhou, S., Chen, L. S., Lin, H., Shen, C., Everett, T. H., Lin, S. F., & Chen, P. S. (2015). Subcut. Heart Rhythm, 12(3), 612-620. https://doi.org/10.1016/j.hrthm.2014.11.007