Subcutaneous wounding postirradiation reduces radiation lethality in mice

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The detonation of an improvised nuclear device during a radiological terrorist attack could result in the exposure of thousands of civilians and first responders to lethal or potentially lethal doses of ionizing radiation (IR). There is a major effort in the United States to develop phamacological mitigators of radiation lethality that would be effective particularly if administered after irradiation. We show here that giving female C57BL/6 mice a subcutaneous surgical incision after whole body exposure to an LD50/30 X-ray dose protects against radiation lethality and increases survival from 50% to over 90% (P = 0.0001). The increase in survival, at least in part, appears to be due to enhanced recovery of hematopoiesis, notably red blood cells, neutrophils and platelets. While a definitive mechanism has yet to be elucidated, we propose that this approach may be used to identify potentially novel mechanisms and pathways that could aid in the development of novel pharmacological radiation countermeasures.

Original languageEnglish
Pages (from-to)578-583
Number of pages6
JournalRadiation Research
Volume181
Issue number6
DOIs
StatePublished - 2014

Fingerprint

lethality
mice
Radiation
nuclear devices
radiation
hematopoiesis
neutrophils
dosage
transponders
countermeasures
Lethal Dose 50
Hematopoiesis
erythrocytes
detonation
Ionizing Radiation
platelets
Inbred C57BL Mouse
ionizing radiation
attack
Neutrophils

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Subcutaneous wounding postirradiation reduces radiation lethality in mice. / Garrett, Joy; Orschell, Christie; Mendonca, Marc; Bigsby, Robert; Dynlacht, Joseph.

In: Radiation Research, Vol. 181, No. 6, 2014, p. 578-583.

Research output: Contribution to journalArticle

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