Subendocardial resection for sustained ventricular tachycardia in the early period after acute myocardial infarction

John Miller, Francis E. Marchlinski, Alden H. Harken, W. Clark Hargrove, Mark E. Josephson

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Abstract

One hundred nineteen patients with drug-refractory ventricular tachycardia (VT) underwent mappingguided subendocardial resection for control of their arrhythmias from 3 weeks to 10 years after acute myocardial infarction (AMI). Patients were separated into 2 groups: those treated early (within 4 months, group I) and those treated later (after 1 year, group II) after AMI. There were 32 patients in group I and 72 patients in group II. Both groups of patients had similar clinical, angiographic and hemodynamlc characteristics. Patients in group I had VT with a shorter mean cycle length than patients in group II (322 ± 71 vs 349 ± 88 ms, p <0.05). The groups did not differ with respect to operative mortality (12% vs 7%), late mortality (31% vs 33%, mean follow-up 23 months), or frequency with which subendocardial resection without any adjunctive therapy prevented postoperative spontaneous or inducible VT (21% vs 34%). Group I was further separated into patients who underwent subendocardial resection within 1 month of AMI (n = 7) and those who underwent subendocardial resection with 2 months of AMI (n = 14). Although patients in group I were characterized by having more spontaneous morphologically distinct tachycardias, their operative mortality, total mortality and surgical success rates were comparable to those of patients in group II. The results of the study suggest that in a patient population with drug-refractory VT after AMI, (1) there are no clinical, angiographic, or hemodynamic variables that distinguish patients in whom VT develops early (within 4 months) from those in whom it develops late (longer than 1 year) after myocardial infarction; (2) VT early after AMI tends to have faster rates and increased number of distinct morphologies; and (3) subendocardial resection early (within 4 months, but even within 1 or 2 months) after AMI is associated with acceptable operative mortality and control of VT.

Original languageEnglish (US)
Pages (from-to)980-984
Number of pages5
JournalThe American Journal of Cardiology
Volume55
Issue number8
DOIs
StatePublished - Apr 1 1985
Externally publishedYes

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Ventricular Tachycardia
Myocardial Infarction
Mortality
Tachycardia
Pharmaceutical Preparations
Cardiac Arrhythmias
Hemodynamics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Subendocardial resection for sustained ventricular tachycardia in the early period after acute myocardial infarction. / Miller, John; Marchlinski, Francis E.; Harken, Alden H.; Hargrove, W. Clark; Josephson, Mark E.

In: The American Journal of Cardiology, Vol. 55, No. 8, 01.04.1985, p. 980-984.

Research output: Contribution to journalArticle

Miller, John ; Marchlinski, Francis E. ; Harken, Alden H. ; Hargrove, W. Clark ; Josephson, Mark E. / Subendocardial resection for sustained ventricular tachycardia in the early period after acute myocardial infarction. In: The American Journal of Cardiology. 1985 ; Vol. 55, No. 8. pp. 980-984.
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