Subependymal giant cell astrocytoma

Jose Bonnin, L. J. Rubinstein, S. Ch Papasozomenos, P. J. Marangos

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Twenty-two cases of subependymal giant cell astrocytoma (SGCA), five of which associated with tuberous sclerosis, were reviewed by conventional neurohistological stains and by peroxidase-antiperoxidase (PAP) immunohistochemistry for glial fibrillary acidic (GFA) protein, the 68 Kd neurofilament subunit (68 Kd-NF), and neuron-specific enolase (NSE). Neurohistological stains confirmed the presence of PTAH-positive fibrils and the absence of Nissl bodies and of neurites originating from the tumor cells. GFA protein-positive cells were present in all tumors not associated with tuberous sclerosis. However, the number of positive cells in each tumor was highly variable. GFA protein-positive cells were rare in the two SGCA accompanying tuberous sclerosis and absent in the remaining three. Neurohistological stains showed no differences between GFA protein-positive and negative cells. 68 Kd-NF-positive cells were found in six tumors. In one tumor, associated with tuberous sclerosis, it was present in the large ganglion-like cells only. NSE-positive cells were found in 13 of 18 tumors examined, including four of the five SGCA associated with tuberous sclerosis. The significance of NSE-positivity in central neuroepithelial neoplasms in respect of their possible neuronal origin remains open. This study suggests that the SGCA, especially those associated with tuberous sclerosis, include cells that are apparently unable to express GFA protein. Some of the tumor cells express the 68 Kd-NF, but this expression falls short of the complete expression of neuronal differentiation. The unique morphological appearances of the SGCA and the discrepancies reported in electron-microscopic and immunohistochemical studies suggest that the cell of origin of these tumors is the product of a dysgenetic event in early development. As a result, the potential of that cell for astrocytic or neuronal differentiation may be incompletely or aberrantly expressed, in particular when the stigmata of tuberous sclerosis are also present. No evidence of obvious ganglionic differentiation and no inference of a neuronal origin of the tumor cells in SGCA could be adduced from the present histochemical findings. This study supports the general interpretation of these tumors as a variant of astrocytoma.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalActa Neuropathologica
Volume62
Issue number3
DOIs
StatePublished - Sep 1984
Externally publishedYes

Fingerprint

Astrocytoma
Tuberous Sclerosis
Glial Fibrillary Acidic Protein
Neoplasms
Intermediate Filaments
Phosphopyruvate Hydratase
Coloring Agents
Nissl Bodies
Neuroepithelial Neoplasms
Christianity
Neurites
Ganglia
Peroxidase
Cell Count
Immunohistochemistry
Electrons

Keywords

  • GFA protein
  • Immunoperoxidase
  • Neuron-specific enolase
  • NF protein
  • Subependymal giant cell astrocytoma

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Bonnin, J., Rubinstein, L. J., Papasozomenos, S. C., & Marangos, P. J. (1984). Subependymal giant cell astrocytoma. Acta Neuropathologica, 62(3), 185-193. https://doi.org/10.1007/BF00691851

Subependymal giant cell astrocytoma. / Bonnin, Jose; Rubinstein, L. J.; Papasozomenos, S. Ch; Marangos, P. J.

In: Acta Neuropathologica, Vol. 62, No. 3, 09.1984, p. 185-193.

Research output: Contribution to journalArticle

Bonnin, J, Rubinstein, LJ, Papasozomenos, SC & Marangos, PJ 1984, 'Subependymal giant cell astrocytoma', Acta Neuropathologica, vol. 62, no. 3, pp. 185-193. https://doi.org/10.1007/BF00691851
Bonnin J, Rubinstein LJ, Papasozomenos SC, Marangos PJ. Subependymal giant cell astrocytoma. Acta Neuropathologica. 1984 Sep;62(3):185-193. https://doi.org/10.1007/BF00691851
Bonnin, Jose ; Rubinstein, L. J. ; Papasozomenos, S. Ch ; Marangos, P. J. / Subependymal giant cell astrocytoma. In: Acta Neuropathologica. 1984 ; Vol. 62, No. 3. pp. 185-193.
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