Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group, SCD-I working group

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.

Original languageEnglish (US)
Pages (from-to)465-476
Number of pages12
JournalAlzheimer's and Dementia
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Dementia
Alzheimer Disease
Incidence
Confidence Intervals
Apolipoprotein E4
Cognitive Dysfunction
Proportional Hazards Models
Multicenter Studies

Keywords

  • Alzheimer's disease
  • Dementia incidence
  • Dementia Lewy bodies
  • Frontotemporal dementia
  • Preclinical Alzheimer's disease
  • Subjective cognitive decline
  • Vascular dementia

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group, & SCD-I working group (2019). Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia. Alzheimer's and Dementia, 15(3), 465-476. https://doi.org/10.1016/j.jalz.2018.10.003

Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia. / Alzheimer's Disease Neuroimaging Initiative; DESCRIPA working group; INSIGHT-preAD study group; SCD-I working group.

In: Alzheimer's and Dementia, Vol. 15, No. 3, 01.03.2019, p. 465-476.

Research output: Contribution to journalArticle

Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group & SCD-I working group 2019, 'Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia', Alzheimer's and Dementia, vol. 15, no. 3, pp. 465-476. https://doi.org/10.1016/j.jalz.2018.10.003
Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group, SCD-I working group. Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia. Alzheimer's and Dementia. 2019 Mar 1;15(3):465-476. https://doi.org/10.1016/j.jalz.2018.10.003
Alzheimer's Disease Neuroimaging Initiative ; DESCRIPA working group ; INSIGHT-preAD study group ; SCD-I working group. / Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia. In: Alzheimer's and Dementia. 2019 ; Vol. 15, No. 3. pp. 465-476.
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abstract = "Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95{\%} Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95{\%} confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.",
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T1 - Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

AU - Alzheimer's Disease Neuroimaging Initiative

AU - DESCRIPA working group

AU - INSIGHT-preAD study group

AU - SCD-I working group

AU - Slot, Rosalinde E.R.

AU - Sikkes, Sietske A.M.

AU - Berkhof, Johannes

AU - Brodaty, Henry

AU - Buckley, Rachel

AU - Cavedo, Enrica

AU - Dardiotis, Efthimios

AU - Guillo-Benarous, Francoise

AU - Hampel, Harald

AU - Kochan, Nicole A.

AU - Lista, Simone

AU - Luck, Tobias

AU - Maruff, Paul

AU - Molinuevo, José Luis

AU - Kornhuber, Johannes

AU - Reisberg, Barry

AU - Riedel-Heller, Steffi G.

AU - Risacher, Shannon L.

AU - Roehr, Susanne

AU - Sachdev, Perminder S.

AU - Scarmeas, Nikolaos

AU - Scheltens, Philip

AU - Shulman, Melanie B.

AU - Saykin, Andrew

AU - Verfaillie, Sander C.J.

AU - Visser, Pieter Jelle

AU - Vos, Stephanie J.B.

AU - Wagner, Michael

AU - Wolfsgruber, Steffen

AU - Jessen, Frank

AU - Boada, Mercè

AU - de Deyn, Peter Paul

AU - Jones, Roy

AU - Frisoni, Giovanni

AU - Spiru, Luiza

AU - Nobili, Flavio

AU - Freund-Levi, Yvonne

AU - Soininen, Hilkka

AU - Verhey, Frans

AU - Wallin, Åsa K.

AU - Touchon, Jacques

AU - Rikkert, Marcel Olde

AU - Rigaud, Anne Sophie

AU - Bullock, Roger

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Wilcock, Gordon

AU - Froelich, Lutz

AU - Bakardjian, Hovagim

AU - Benali, Habib

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.

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KW - Alzheimer's disease

KW - Dementia incidence

KW - Dementia Lewy bodies

KW - Frontotemporal dementia

KW - Preclinical Alzheimer's disease

KW - Subjective cognitive decline

KW - Vascular dementia

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