Subjective intoxication in response to alcohol challenge

Heritability and covariation with personality, breath alcohol level, and drinking history

Richard J. Viken, Richard J. Rose, Sandra Morzorati, Joe C. Christian, Ting Kai Li

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Background: Numerous studies have identified differences in subjective response to alcohol in subjects differentiated by family history of alcoholism. Results suggest that genetic influences on individual variation in subjective response to alcohol may be a mechanism for genetic effects on alcohol problems. However, direct evidence for genetic effects on subjective response to alcohol is very limited. Methods: In a sample of 99 adult twin pairs, we studied genetic influences on subjective intoxication after alcohol challenge. The twins ingested a standard dose of ethanol (0.70 g/kg for men/0.65 g/kg for women), and two measures of subjective response to alcohol were assessed. Results: Genetic effects on variation in subjective intoxication reported 1 hr after drinking were significant and substantial: heritability was 0.60 for a 22-item scale and 0.48 for a brief 2-item measure. Self-report measures of neuroticism, psychasthenia, hostility, and family problems shared significant genetic covariation with subjective intoxication. Achieved breath alcohol level, rate of change in breath alcohol on the descending limb, and individual drinking history all shared familial variation with subjective intoxication. No significant genetic effects for subjective intoxication were found 2 hr after drinking, but familial influences remained present, and many of the same personality, drinking history, and breath alcohol variables were predictive of intoxication. Conclusions: Subjective response to alcohol is heritable, and genetic effects on subjective intoxication are partly shared with genetic effects on personality.

Original languageEnglish
Pages (from-to)795-803
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume27
Issue number5
DOIs
StatePublished - May 1 2003

Fingerprint

Alcohol Drinking
Personality
History
Alcohols
Drinking
Alcoholic Intoxication
Hostility
Self Report
Alcoholism
Ethanol
Extremities

Keywords

  • Alcohol
  • Heritability
  • Personality
  • Subjective Intoxication
  • Twins

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Subjective intoxication in response to alcohol challenge : Heritability and covariation with personality, breath alcohol level, and drinking history. / Viken, Richard J.; Rose, Richard J.; Morzorati, Sandra; Christian, Joe C.; Li, Ting Kai.

In: Alcoholism: Clinical and Experimental Research, Vol. 27, No. 5, 01.05.2003, p. 795-803.

Research output: Contribution to journalArticle

@article{a9d462f8f0ac43449798f4add7695425,
title = "Subjective intoxication in response to alcohol challenge: Heritability and covariation with personality, breath alcohol level, and drinking history",
abstract = "Background: Numerous studies have identified differences in subjective response to alcohol in subjects differentiated by family history of alcoholism. Results suggest that genetic influences on individual variation in subjective response to alcohol may be a mechanism for genetic effects on alcohol problems. However, direct evidence for genetic effects on subjective response to alcohol is very limited. Methods: In a sample of 99 adult twin pairs, we studied genetic influences on subjective intoxication after alcohol challenge. The twins ingested a standard dose of ethanol (0.70 g/kg for men/0.65 g/kg for women), and two measures of subjective response to alcohol were assessed. Results: Genetic effects on variation in subjective intoxication reported 1 hr after drinking were significant and substantial: heritability was 0.60 for a 22-item scale and 0.48 for a brief 2-item measure. Self-report measures of neuroticism, psychasthenia, hostility, and family problems shared significant genetic covariation with subjective intoxication. Achieved breath alcohol level, rate of change in breath alcohol on the descending limb, and individual drinking history all shared familial variation with subjective intoxication. No significant genetic effects for subjective intoxication were found 2 hr after drinking, but familial influences remained present, and many of the same personality, drinking history, and breath alcohol variables were predictive of intoxication. Conclusions: Subjective response to alcohol is heritable, and genetic effects on subjective intoxication are partly shared with genetic effects on personality.",
keywords = "Alcohol, Heritability, Personality, Subjective Intoxication, Twins",
author = "Viken, {Richard J.} and Rose, {Richard J.} and Sandra Morzorati and Christian, {Joe C.} and Li, {Ting Kai}",
year = "2003",
month = "5",
day = "1",
doi = "10.1097/01.ALC.0000067974.41160.95",
language = "English",
volume = "27",
pages = "795--803",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Subjective intoxication in response to alcohol challenge

T2 - Heritability and covariation with personality, breath alcohol level, and drinking history

AU - Viken, Richard J.

AU - Rose, Richard J.

AU - Morzorati, Sandra

AU - Christian, Joe C.

AU - Li, Ting Kai

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Background: Numerous studies have identified differences in subjective response to alcohol in subjects differentiated by family history of alcoholism. Results suggest that genetic influences on individual variation in subjective response to alcohol may be a mechanism for genetic effects on alcohol problems. However, direct evidence for genetic effects on subjective response to alcohol is very limited. Methods: In a sample of 99 adult twin pairs, we studied genetic influences on subjective intoxication after alcohol challenge. The twins ingested a standard dose of ethanol (0.70 g/kg for men/0.65 g/kg for women), and two measures of subjective response to alcohol were assessed. Results: Genetic effects on variation in subjective intoxication reported 1 hr after drinking were significant and substantial: heritability was 0.60 for a 22-item scale and 0.48 for a brief 2-item measure. Self-report measures of neuroticism, psychasthenia, hostility, and family problems shared significant genetic covariation with subjective intoxication. Achieved breath alcohol level, rate of change in breath alcohol on the descending limb, and individual drinking history all shared familial variation with subjective intoxication. No significant genetic effects for subjective intoxication were found 2 hr after drinking, but familial influences remained present, and many of the same personality, drinking history, and breath alcohol variables were predictive of intoxication. Conclusions: Subjective response to alcohol is heritable, and genetic effects on subjective intoxication are partly shared with genetic effects on personality.

AB - Background: Numerous studies have identified differences in subjective response to alcohol in subjects differentiated by family history of alcoholism. Results suggest that genetic influences on individual variation in subjective response to alcohol may be a mechanism for genetic effects on alcohol problems. However, direct evidence for genetic effects on subjective response to alcohol is very limited. Methods: In a sample of 99 adult twin pairs, we studied genetic influences on subjective intoxication after alcohol challenge. The twins ingested a standard dose of ethanol (0.70 g/kg for men/0.65 g/kg for women), and two measures of subjective response to alcohol were assessed. Results: Genetic effects on variation in subjective intoxication reported 1 hr after drinking were significant and substantial: heritability was 0.60 for a 22-item scale and 0.48 for a brief 2-item measure. Self-report measures of neuroticism, psychasthenia, hostility, and family problems shared significant genetic covariation with subjective intoxication. Achieved breath alcohol level, rate of change in breath alcohol on the descending limb, and individual drinking history all shared familial variation with subjective intoxication. No significant genetic effects for subjective intoxication were found 2 hr after drinking, but familial influences remained present, and many of the same personality, drinking history, and breath alcohol variables were predictive of intoxication. Conclusions: Subjective response to alcohol is heritable, and genetic effects on subjective intoxication are partly shared with genetic effects on personality.

KW - Alcohol

KW - Heritability

KW - Personality

KW - Subjective Intoxication

KW - Twins

UR - http://www.scopus.com/inward/record.url?scp=0038662890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038662890&partnerID=8YFLogxK

U2 - 10.1097/01.ALC.0000067974.41160.95

DO - 10.1097/01.ALC.0000067974.41160.95

M3 - Article

VL - 27

SP - 795

EP - 803

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 5

ER -