Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex

Charles T. Anderson, Patrick Sheets, Taro Kiritani, Gordon M G Shepherd

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The mammalian motor system is organized around distinct subcortical subsystems, suggesting that the intracortical circuits immediately upstream of spinal cord and basal ganglia might be functionally differentiated as well. We found that the main excitatory pathway in mouse motor cortex, layer 2/3→5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, which are involved in motor control. However, connections were selective for neurons in certain sublayers: corticospinal neurons in upper layer 5B and corticostriatal neurons in lower 5A. A simple structural combinatorial principle accounts for this highly specific functional circuit architecture: potential connectivity is established by neuronal sublayer positioning and actual connectivity in this framework is determined by long-range axonal projection targets. Thus, intracortical circuits of these pyramidal neurons are specified not only by their long-range axonal targets or their layer or sublayer positions, but by both, in specific combinations.

Original languageEnglish (US)
Pages (from-to)739-744
Number of pages6
JournalNature Neuroscience
Volume13
Issue number6
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

Motor Cortex
Neurons
Pyramidal Cells
Spinal Ganglia
Basal Ganglia
Spinal Cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex. / Anderson, Charles T.; Sheets, Patrick; Kiritani, Taro; Shepherd, Gordon M G.

In: Nature Neuroscience, Vol. 13, No. 6, 06.2010, p. 739-744.

Research output: Contribution to journalArticle

Anderson, Charles T. ; Sheets, Patrick ; Kiritani, Taro ; Shepherd, Gordon M G. / Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex. In: Nature Neuroscience. 2010 ; Vol. 13, No. 6. pp. 739-744.
@article{332501a85c7746209a39c47657c5a815,
title = "Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex",
abstract = "The mammalian motor system is organized around distinct subcortical subsystems, suggesting that the intracortical circuits immediately upstream of spinal cord and basal ganglia might be functionally differentiated as well. We found that the main excitatory pathway in mouse motor cortex, layer 2/3→5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, which are involved in motor control. However, connections were selective for neurons in certain sublayers: corticospinal neurons in upper layer 5B and corticostriatal neurons in lower 5A. A simple structural combinatorial principle accounts for this highly specific functional circuit architecture: potential connectivity is established by neuronal sublayer positioning and actual connectivity in this framework is determined by long-range axonal projection targets. Thus, intracortical circuits of these pyramidal neurons are specified not only by their long-range axonal targets or their layer or sublayer positions, but by both, in specific combinations.",
author = "Anderson, {Charles T.} and Patrick Sheets and Taro Kiritani and Shepherd, {Gordon M G}",
year = "2010",
month = "6",
doi = "10.1038/nn.2538",
language = "English (US)",
volume = "13",
pages = "739--744",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex

AU - Anderson, Charles T.

AU - Sheets, Patrick

AU - Kiritani, Taro

AU - Shepherd, Gordon M G

PY - 2010/6

Y1 - 2010/6

N2 - The mammalian motor system is organized around distinct subcortical subsystems, suggesting that the intracortical circuits immediately upstream of spinal cord and basal ganglia might be functionally differentiated as well. We found that the main excitatory pathway in mouse motor cortex, layer 2/3→5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, which are involved in motor control. However, connections were selective for neurons in certain sublayers: corticospinal neurons in upper layer 5B and corticostriatal neurons in lower 5A. A simple structural combinatorial principle accounts for this highly specific functional circuit architecture: potential connectivity is established by neuronal sublayer positioning and actual connectivity in this framework is determined by long-range axonal projection targets. Thus, intracortical circuits of these pyramidal neurons are specified not only by their long-range axonal targets or their layer or sublayer positions, but by both, in specific combinations.

AB - The mammalian motor system is organized around distinct subcortical subsystems, suggesting that the intracortical circuits immediately upstream of spinal cord and basal ganglia might be functionally differentiated as well. We found that the main excitatory pathway in mouse motor cortex, layer 2/3→5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, which are involved in motor control. However, connections were selective for neurons in certain sublayers: corticospinal neurons in upper layer 5B and corticostriatal neurons in lower 5A. A simple structural combinatorial principle accounts for this highly specific functional circuit architecture: potential connectivity is established by neuronal sublayer positioning and actual connectivity in this framework is determined by long-range axonal projection targets. Thus, intracortical circuits of these pyramidal neurons are specified not only by their long-range axonal targets or their layer or sublayer positions, but by both, in specific combinations.

UR - http://www.scopus.com/inward/record.url?scp=77952887219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952887219&partnerID=8YFLogxK

U2 - 10.1038/nn.2538

DO - 10.1038/nn.2538

M3 - Article

VL - 13

SP - 739

EP - 744

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 6

ER -