Subsequent sexually transmitted infection in urban adolescents and young adults

D. P. Orr, K. Johnston, E. Brizendine, Barry Katz, J. Fortenberry

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objective: To compare the rates of subsequent infection with Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis in a group of high-risk adolescents and young adults. Methods: At the time of treatment, 444 unmarried teenagers and young adults aged 13 to 25 years were enrolled from an urban sexually transmitted disease clinic and 3 community-based primary care clinics. Subjects were infected with C trachomatis, N gonorrhoeae, or T vaginalis, were diagnosed as having nongonococcal urethritis (in men), or were uninfected sexual contacts with one of these infections. Subjects returned at 1, 3, 5, and 7 months. Results: The rate of subsequent infection was substantial. Forty percent of men and 53% of women who were uninfected contacts at enrollment were estimated to be infected within 7 months; 60% of men and 73% of women infected at enrollment were estimated to be reinfected. Among women, subjects who were infected at enrollment had a shorter time to subsequent infection (median, 140 days) compared with uninfected contacts (median, 209 days) (P=.04). Among men, findings were similar, but the difference in median time to subsequent infection was not significant (P=.08). Baseline characteristics that predicted shorter time to reinfection were female sex and infection at enrollment. When sexual behaviors in the 2 months preceding each subsequent data collection visit were included in the model, only being female and reporting at least one new interval sexual partner were significant predictors of subsequent sexually transmitted infections. Conclusions: These data support recent research that has found high rates of subsequent infection among high-risk adolescents and young adults. Contacts of a sexually transmitted infection appear to be at equally high risk for subsequent infection as those with a personal history of infection. Our data suggest that more frequent than annual screening for N gonorrhoeae, C trachomatis, and T vaginalis would be appropriate in at-risk adolescent and young adult populations, including individuals who are uninfected sexual contacts to a sexually transmitted infection.

Original languageEnglish
Pages (from-to)947-953
Number of pages7
JournalArchives of Pediatrics and Adolescent Medicine
Volume155
Issue number8
StatePublished - 2001

Fingerprint

Sexually Transmitted Diseases
Young Adult
Infection
Gonorrhea
Trichomonas vaginalis
Urethritis
Neisseria gonorrhoeae
Sexual Partners
Chlamydia trachomatis
Sexual Behavior
Primary Health Care
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Subsequent sexually transmitted infection in urban adolescents and young adults. / Orr, D. P.; Johnston, K.; Brizendine, E.; Katz, Barry; Fortenberry, J.

In: Archives of Pediatrics and Adolescent Medicine, Vol. 155, No. 8, 2001, p. 947-953.

Research output: Contribution to journalArticle

@article{9a7dd51bfc6c441b8794d2a820ad13dc,
title = "Subsequent sexually transmitted infection in urban adolescents and young adults",
abstract = "Objective: To compare the rates of subsequent infection with Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis in a group of high-risk adolescents and young adults. Methods: At the time of treatment, 444 unmarried teenagers and young adults aged 13 to 25 years were enrolled from an urban sexually transmitted disease clinic and 3 community-based primary care clinics. Subjects were infected with C trachomatis, N gonorrhoeae, or T vaginalis, were diagnosed as having nongonococcal urethritis (in men), or were uninfected sexual contacts with one of these infections. Subjects returned at 1, 3, 5, and 7 months. Results: The rate of subsequent infection was substantial. Forty percent of men and 53{\%} of women who were uninfected contacts at enrollment were estimated to be infected within 7 months; 60{\%} of men and 73{\%} of women infected at enrollment were estimated to be reinfected. Among women, subjects who were infected at enrollment had a shorter time to subsequent infection (median, 140 days) compared with uninfected contacts (median, 209 days) (P=.04). Among men, findings were similar, but the difference in median time to subsequent infection was not significant (P=.08). Baseline characteristics that predicted shorter time to reinfection were female sex and infection at enrollment. When sexual behaviors in the 2 months preceding each subsequent data collection visit were included in the model, only being female and reporting at least one new interval sexual partner were significant predictors of subsequent sexually transmitted infections. Conclusions: These data support recent research that has found high rates of subsequent infection among high-risk adolescents and young adults. Contacts of a sexually transmitted infection appear to be at equally high risk for subsequent infection as those with a personal history of infection. Our data suggest that more frequent than annual screening for N gonorrhoeae, C trachomatis, and T vaginalis would be appropriate in at-risk adolescent and young adult populations, including individuals who are uninfected sexual contacts to a sexually transmitted infection.",
author = "Orr, {D. P.} and K. Johnston and E. Brizendine and Barry Katz and J. Fortenberry",
year = "2001",
language = "English",
volume = "155",
pages = "947--953",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association",
number = "8",

}

TY - JOUR

T1 - Subsequent sexually transmitted infection in urban adolescents and young adults

AU - Orr, D. P.

AU - Johnston, K.

AU - Brizendine, E.

AU - Katz, Barry

AU - Fortenberry, J.

PY - 2001

Y1 - 2001

N2 - Objective: To compare the rates of subsequent infection with Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis in a group of high-risk adolescents and young adults. Methods: At the time of treatment, 444 unmarried teenagers and young adults aged 13 to 25 years were enrolled from an urban sexually transmitted disease clinic and 3 community-based primary care clinics. Subjects were infected with C trachomatis, N gonorrhoeae, or T vaginalis, were diagnosed as having nongonococcal urethritis (in men), or were uninfected sexual contacts with one of these infections. Subjects returned at 1, 3, 5, and 7 months. Results: The rate of subsequent infection was substantial. Forty percent of men and 53% of women who were uninfected contacts at enrollment were estimated to be infected within 7 months; 60% of men and 73% of women infected at enrollment were estimated to be reinfected. Among women, subjects who were infected at enrollment had a shorter time to subsequent infection (median, 140 days) compared with uninfected contacts (median, 209 days) (P=.04). Among men, findings were similar, but the difference in median time to subsequent infection was not significant (P=.08). Baseline characteristics that predicted shorter time to reinfection were female sex and infection at enrollment. When sexual behaviors in the 2 months preceding each subsequent data collection visit were included in the model, only being female and reporting at least one new interval sexual partner were significant predictors of subsequent sexually transmitted infections. Conclusions: These data support recent research that has found high rates of subsequent infection among high-risk adolescents and young adults. Contacts of a sexually transmitted infection appear to be at equally high risk for subsequent infection as those with a personal history of infection. Our data suggest that more frequent than annual screening for N gonorrhoeae, C trachomatis, and T vaginalis would be appropriate in at-risk adolescent and young adult populations, including individuals who are uninfected sexual contacts to a sexually transmitted infection.

AB - Objective: To compare the rates of subsequent infection with Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis in a group of high-risk adolescents and young adults. Methods: At the time of treatment, 444 unmarried teenagers and young adults aged 13 to 25 years were enrolled from an urban sexually transmitted disease clinic and 3 community-based primary care clinics. Subjects were infected with C trachomatis, N gonorrhoeae, or T vaginalis, were diagnosed as having nongonococcal urethritis (in men), or were uninfected sexual contacts with one of these infections. Subjects returned at 1, 3, 5, and 7 months. Results: The rate of subsequent infection was substantial. Forty percent of men and 53% of women who were uninfected contacts at enrollment were estimated to be infected within 7 months; 60% of men and 73% of women infected at enrollment were estimated to be reinfected. Among women, subjects who were infected at enrollment had a shorter time to subsequent infection (median, 140 days) compared with uninfected contacts (median, 209 days) (P=.04). Among men, findings were similar, but the difference in median time to subsequent infection was not significant (P=.08). Baseline characteristics that predicted shorter time to reinfection were female sex and infection at enrollment. When sexual behaviors in the 2 months preceding each subsequent data collection visit were included in the model, only being female and reporting at least one new interval sexual partner were significant predictors of subsequent sexually transmitted infections. Conclusions: These data support recent research that has found high rates of subsequent infection among high-risk adolescents and young adults. Contacts of a sexually transmitted infection appear to be at equally high risk for subsequent infection as those with a personal history of infection. Our data suggest that more frequent than annual screening for N gonorrhoeae, C trachomatis, and T vaginalis would be appropriate in at-risk adolescent and young adult populations, including individuals who are uninfected sexual contacts to a sexually transmitted infection.

UR - http://www.scopus.com/inward/record.url?scp=0034911121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034911121&partnerID=8YFLogxK

M3 - Article

VL - 155

SP - 947

EP - 953

JO - JAMA Pediatrics

JF - JAMA Pediatrics

SN - 2168-6203

IS - 8

ER -