Success with Extended-Infusion Meropenem after Recurrence of Baclofen Pump-Related Achromobacter Xylosoxidans Meningitis in an Adolescent

Kristen R. Nichols, Chad A. Knoderer, Nicholas G. Jackson, John J. Manaloor, John C. Christenson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A 13-year-old female experienced a recurrence of baclofen pump-related central nervous system (CNS) infection caused by Achromobacter, despite absence of retained foreign material. Due to the failure of meropenem (120 mg/kg/d in divided doses every 8 hours and infused over 30 minutes) in the initial infection, the dose was infused over 4 hours during the recurrence. Meropenem is an antibiotic for which efficacy is time dependent, and 4-hour versus 30-minute infusions have been shown to prolong the time the concentration of the antibiotic exceeds the minimum inhibitory concentration (MIC) of the organism at the site of infection (T>MIC). Meropenem serum concentrations were obtained and indicated that T>MIC was at least 75% of the dosing interval. Our patient improved with no noted recurrences or adverse effects on the extended-infusion meropenem regimen. Utilization of extended-infusion beta-lactam dosing whenever possible in the treatment of serious infections caused by gram-negative organisms should be considered, as this dosing appears to be safe and improves the probability of achieving pharmacokinetic/pharmacodynamic goals.

Original languageEnglish (US)
Pages (from-to)430-433
Number of pages4
JournalJournal of Pharmacy Practice
Volume28
Issue number4
DOIs
StatePublished - Aug 25 2015

Keywords

  • Achromobacter
  • device infection
  • meningitis
  • meropenem
  • pharmacodynamics

ASJC Scopus subject areas

  • Pharmacology (medical)

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