Sudden cardiac death, genes, and arrhythmogenesis: Consideration of new population and mechanistic approaches from a National Heart, Lung, and Blood Institute workshop, part I

Peter M. Spooner, Christine Albert, Emelia J. Benjamin, Robin Boineau, Robert C. Elston, Alfred L. George, Xavier Jouven, Lewis H. Kuller, Jean W. MacCluer, Eduardo Marbán, James E. Muller, Peter J. Schwartz, David S. Siscovick, Russell P. Tracy, Wojciech Zareba, Douglas P. Zipes

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Malignant ventricular arrhythmias are the leading mechanism of death in patients with acute and chronic cardiac pathologies. The extent to which inherited mutations and polymorphic variation in genes determining arrhythmogenic mechanisms affect these patients remains unknown, but based on recent population studies, this risk appears significant, deserving much greater investigation. This report summarizes a National Heart, Lung, and Blood Institute workshop that considered sources of genetic variation that may contribute to sudden cardiac death in common cardiac diseases. Evidence on arrhythmogenic mechanisms in recent population studies suggests a significant portion of the risk of sudden cardiac death in such broad populations may be unrelated to traditional risk factors for predisposing conditions such as atherosclerosis, hypertension, and diabetes and instead may involve unrecognized genetic and environmental interactions that influence arrhythmic susceptibility more directly. Additional population and genetic studies directed at discovering the sources of inherited molecular risk that are most directly linked to arrhythmia initiation and propagation, in addition to studies on previously well-described risk factors, would appear to have considerable potential for reducing premature cardiovascular mortality.

Original languageEnglish (US)
Pages (from-to)2361-2364
Number of pages4
JournalCirculation
Volume103
Issue number19
DOIs
StatePublished - May 15 2001

Keywords

  • Arrhythmia
  • Death, sudden
  • Epidemiology
  • Genetics
  • Ion channels
  • Mortality
  • Tachyarrhythmias

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Spooner, P. M., Albert, C., Benjamin, E. J., Boineau, R., Elston, R. C., George, A. L., Jouven, X., Kuller, L. H., MacCluer, J. W., Marbán, E., Muller, J. E., Schwartz, P. J., Siscovick, D. S., Tracy, R. P., Zareba, W., & Zipes, D. P. (2001). Sudden cardiac death, genes, and arrhythmogenesis: Consideration of new population and mechanistic approaches from a National Heart, Lung, and Blood Institute workshop, part I. Circulation, 103(19), 2361-2364. https://doi.org/10.1161/01.CIR.103.19.2361