Sudden cardiac death prediction and prevention: Report from a national heart, lung, and blood institute and heart rhythm society workshop

Glenn I. Fishman, Sumeet S. Chugh, John P. Dimarco, Christine M. Albert, Mark E. Anderson, Robert O. Bonow, Alfred E. Buxton, Peng Sheng Chen, Mark Estes, Xavier Jouven, Raymond Kwong, David A. Lathrop, Alice M. Mascette, Jeanne M. Nerbonne, Brian O'Rourke, Richard L. Page, Dan M. Roden, David S. Rosenbaum, Nona Sotoodehnia, Natalia A. TrayanovaZhi Jie Zheng

Research output: Contribution to journalArticle

373 Scopus citations

Abstract

The prediction and prevention of SCD remains an enormous challenge. Despite the accumulation of remarkable insight into the genetic basis and regulation of cardiac excitability, translation of this knowledge into novel strategies to identify the majority of individuals at risk of SCD is lacking, as it has targeted antiarrhythmic therapy. Translating new genetic information into improved understanding of physiology and disease represents a bottleneck to progress in mechanistic SCD research. Recent population, clinical, and basic science research studies, however, suggest there are real opportunities to improve our ability to identify individuals at moderate and high risk of SCD and to intervene to diminish such risk. Nonetheless, the complexity of the problem cannot be overstated and integrative strategies spanning a broad range of scales from molecular through organism and population studies, will be required to make progress in this area.

Original languageEnglish (US)
Pages (from-to)2335-2348
Number of pages14
JournalCirculation
Volume122
Issue number22
DOIs
StatePublished - Nov 30 2010

Keywords

  • electrophysiology
  • epidemiology
  • National Heart, Lung, and Blood Institute
  • prevention
  • sudden cardiac death

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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    Fishman, G. I., Chugh, S. S., Dimarco, J. P., Albert, C. M., Anderson, M. E., Bonow, R. O., Buxton, A. E., Chen, P. S., Estes, M., Jouven, X., Kwong, R., Lathrop, D. A., Mascette, A. M., Nerbonne, J. M., O'Rourke, B., Page, R. L., Roden, D. M., Rosenbaum, D. S., Sotoodehnia, N., ... Zheng, Z. J. (2010). Sudden cardiac death prediction and prevention: Report from a national heart, lung, and blood institute and heart rhythm society workshop. Circulation, 122(22), 2335-2348. https://doi.org/10.1161/CIRCULATIONAHA.110.976092