Sudden death in the presence of overt β-adrenergic receptor activation in guinea pigs immediately following isoflurane anesthesia

Brian R. Overholser, Xiaomei Zheng, Carrie Pell, Andrew Blickman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Observations: A case series of sudden death is reported in five consecutive guinea pigs following anesthesia with inhalational isoflurane during β-adrenergic receptor stimulation with isoproterenol. Sustained-release isoproterenol pellets or mini-osmotic pumps were implanted subcutaneously in male Dunkin-Hartley guinea pigs as part of a research study to assess the interplay of adrenergic receptor activation and the development of atrial arrhythmias. The continuous exposure to isoproterenol resulted in a similar presentation and eventual sudden death in all guinea pigs exposed to inhalational isoflurane between 15 to 40 minutes after discontinuation of anesthesia. Death occurred in guinea pigs in this case series despite the fact that doses of isoproterenol used were more than 10-fold lower than previously reported in guinea pigs in the absence of isoflurane anesthesia. The cause of death was suspected to be due to an interaction of isoproterenol with isoflurane anesthesia, as placebo implantation or anesthesia alone did not result in cardiac arrest. Of four subsequent guinea pigs anesthetized with the combination of xylazine and ketamine (X/K), three survived isoproterenol implantation for the full 21-day study period while one died perioperatively. Conclusions: There was an increased rate of post-anesthetic mortality associated with isoproterenol pellet implantation in guinea pigs anesthetized with isoflurane compared to X/K. This may be due to the detrimental effects of the combination of isoflurane during overt β-adrenergic receptor activation or cardioprotective effects of X/K anesthesia during β-adrenergic receptor hyperactivity.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalVeterinary Anaesthesia and Analgesia
Volume37
Issue number3
DOIs
StatePublished - May 2010

Fingerprint

Isoflurane
isoflurane
adrenergic receptors
Sudden Death
Isoproterenol
guinea pigs
Adrenergic Receptors
anesthesia
Guinea Pigs
Anesthesia
death
Xylazine
xylazine
Ketamine
ketamine
pellets
cardioprotective effect
cardiac arrest
arrhythmia
Heart Arrest

Keywords

  • β-adrenergic receptor
  • Anesthesia
  • Guinea pigs
  • Isoflurane
  • Isoproterenol

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Sudden death in the presence of overt β-adrenergic receptor activation in guinea pigs immediately following isoflurane anesthesia. / Overholser, Brian R.; Zheng, Xiaomei; Pell, Carrie; Blickman, Andrew.

In: Veterinary Anaesthesia and Analgesia, Vol. 37, No. 3, 05.2010, p. 273-279.

Research output: Contribution to journalArticle

Overholser, Brian R. ; Zheng, Xiaomei ; Pell, Carrie ; Blickman, Andrew. / Sudden death in the presence of overt β-adrenergic receptor activation in guinea pigs immediately following isoflurane anesthesia. In: Veterinary Anaesthesia and Analgesia. 2010 ; Vol. 37, No. 3. pp. 273-279.
@article{7c6eabe5b70a44088bdd9fb52b6499e1,
title = "Sudden death in the presence of overt β-adrenergic receptor activation in guinea pigs immediately following isoflurane anesthesia",
abstract = "Observations: A case series of sudden death is reported in five consecutive guinea pigs following anesthesia with inhalational isoflurane during β-adrenergic receptor stimulation with isoproterenol. Sustained-release isoproterenol pellets or mini-osmotic pumps were implanted subcutaneously in male Dunkin-Hartley guinea pigs as part of a research study to assess the interplay of adrenergic receptor activation and the development of atrial arrhythmias. The continuous exposure to isoproterenol resulted in a similar presentation and eventual sudden death in all guinea pigs exposed to inhalational isoflurane between 15 to 40 minutes after discontinuation of anesthesia. Death occurred in guinea pigs in this case series despite the fact that doses of isoproterenol used were more than 10-fold lower than previously reported in guinea pigs in the absence of isoflurane anesthesia. The cause of death was suspected to be due to an interaction of isoproterenol with isoflurane anesthesia, as placebo implantation or anesthesia alone did not result in cardiac arrest. Of four subsequent guinea pigs anesthetized with the combination of xylazine and ketamine (X/K), three survived isoproterenol implantation for the full 21-day study period while one died perioperatively. Conclusions: There was an increased rate of post-anesthetic mortality associated with isoproterenol pellet implantation in guinea pigs anesthetized with isoflurane compared to X/K. This may be due to the detrimental effects of the combination of isoflurane during overt β-adrenergic receptor activation or cardioprotective effects of X/K anesthesia during β-adrenergic receptor hyperactivity.",
keywords = "β-adrenergic receptor, Anesthesia, Guinea pigs, Isoflurane, Isoproterenol",
author = "Overholser, {Brian R.} and Xiaomei Zheng and Carrie Pell and Andrew Blickman",
year = "2010",
month = "5",
doi = "10.1111/j.1467-2995.2010.00533.x",
language = "English",
volume = "37",
pages = "273--279",
journal = "Veterinary Anaesthesia and Analgesia",
issn = "1467-2987",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Sudden death in the presence of overt β-adrenergic receptor activation in guinea pigs immediately following isoflurane anesthesia

AU - Overholser, Brian R.

AU - Zheng, Xiaomei

AU - Pell, Carrie

AU - Blickman, Andrew

PY - 2010/5

Y1 - 2010/5

N2 - Observations: A case series of sudden death is reported in five consecutive guinea pigs following anesthesia with inhalational isoflurane during β-adrenergic receptor stimulation with isoproterenol. Sustained-release isoproterenol pellets or mini-osmotic pumps were implanted subcutaneously in male Dunkin-Hartley guinea pigs as part of a research study to assess the interplay of adrenergic receptor activation and the development of atrial arrhythmias. The continuous exposure to isoproterenol resulted in a similar presentation and eventual sudden death in all guinea pigs exposed to inhalational isoflurane between 15 to 40 minutes after discontinuation of anesthesia. Death occurred in guinea pigs in this case series despite the fact that doses of isoproterenol used were more than 10-fold lower than previously reported in guinea pigs in the absence of isoflurane anesthesia. The cause of death was suspected to be due to an interaction of isoproterenol with isoflurane anesthesia, as placebo implantation or anesthesia alone did not result in cardiac arrest. Of four subsequent guinea pigs anesthetized with the combination of xylazine and ketamine (X/K), three survived isoproterenol implantation for the full 21-day study period while one died perioperatively. Conclusions: There was an increased rate of post-anesthetic mortality associated with isoproterenol pellet implantation in guinea pigs anesthetized with isoflurane compared to X/K. This may be due to the detrimental effects of the combination of isoflurane during overt β-adrenergic receptor activation or cardioprotective effects of X/K anesthesia during β-adrenergic receptor hyperactivity.

AB - Observations: A case series of sudden death is reported in five consecutive guinea pigs following anesthesia with inhalational isoflurane during β-adrenergic receptor stimulation with isoproterenol. Sustained-release isoproterenol pellets or mini-osmotic pumps were implanted subcutaneously in male Dunkin-Hartley guinea pigs as part of a research study to assess the interplay of adrenergic receptor activation and the development of atrial arrhythmias. The continuous exposure to isoproterenol resulted in a similar presentation and eventual sudden death in all guinea pigs exposed to inhalational isoflurane between 15 to 40 minutes after discontinuation of anesthesia. Death occurred in guinea pigs in this case series despite the fact that doses of isoproterenol used were more than 10-fold lower than previously reported in guinea pigs in the absence of isoflurane anesthesia. The cause of death was suspected to be due to an interaction of isoproterenol with isoflurane anesthesia, as placebo implantation or anesthesia alone did not result in cardiac arrest. Of four subsequent guinea pigs anesthetized with the combination of xylazine and ketamine (X/K), three survived isoproterenol implantation for the full 21-day study period while one died perioperatively. Conclusions: There was an increased rate of post-anesthetic mortality associated with isoproterenol pellet implantation in guinea pigs anesthetized with isoflurane compared to X/K. This may be due to the detrimental effects of the combination of isoflurane during overt β-adrenergic receptor activation or cardioprotective effects of X/K anesthesia during β-adrenergic receptor hyperactivity.

KW - β-adrenergic receptor

KW - Anesthesia

KW - Guinea pigs

KW - Isoflurane

KW - Isoproterenol

UR - http://www.scopus.com/inward/record.url?scp=77955071268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955071268&partnerID=8YFLogxK

U2 - 10.1111/j.1467-2995.2010.00533.x

DO - 10.1111/j.1467-2995.2010.00533.x

M3 - Article

VL - 37

SP - 273

EP - 279

JO - Veterinary Anaesthesia and Analgesia

JF - Veterinary Anaesthesia and Analgesia

SN - 1467-2987

IS - 3

ER -