Suggested Guidelines for Patient Monitoring: Hepatic and Hematologic Toxicity Attributable to Systemic Dermatologic Drugs

Stephen Wolverton, Kathleen Remlinger

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Hepatic and hematologic toxicity are among the most fearful adverse effects that occasionally occur as a result of systemic drugs in the dermatologist's therapeutic armamentarium. Drugs of greatest interest concerning hepatic toxicity include methotrexate, azathioprine, dapsone, and acitretin. Somewhat overlapping are drugs that have important hematologic toxicities, including methotrexate, azathioprine, dapsone, sulfonamides, cyclophosphamide, and chlorambucil. Laboratory tests most commonly used include (1) hepatic monitoring: transaminases (AST/SGOT and ALT/SGPT) and the ultrasound-guided liver biopsy, and (2) hematologic monitoring: CBC with diff and platelets along with occasional use of the reticulocyte count. Important principles and specific guidelines for monitoring by drug group are highlighted.

Original languageEnglish
Pages (from-to)195-205
Number of pages11
JournalDermatologic Clinics
Volume25
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

Physiologic Monitoring
Guidelines
Dapsone
Liver
Azathioprine
Methotrexate
Pharmaceutical Preparations
Acitretin
Reticulocyte Count
Chlorambucil
Drug Monitoring
Sulfonamides
Aspartate Aminotransferases
Transaminases
Alanine Transaminase
Cyclophosphamide
Blood Platelets
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Suggested Guidelines for Patient Monitoring : Hepatic and Hematologic Toxicity Attributable to Systemic Dermatologic Drugs. / Wolverton, Stephen; Remlinger, Kathleen.

In: Dermatologic Clinics, Vol. 25, No. 2, 04.2007, p. 195-205.

Research output: Contribution to journalArticle

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