Sulpiride: A weak antagonist of norepinephrine and 5-hydroxytryptamine

Jai D. Kohli, Larry D. Cripe

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Antagonism of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) by sulpiride was studied in vitro on rabbit aortic strips. Concentrations of sulpiride ranging from 3 × 10-5 to 3 × 10-3 M caused a progressive shift of the dose response curves of both NE and 5-HT to the right without inhibiting the responses to KCl. pA2 values of sulpiride calculated from Schild plots against NE and 5-HT were 4.6 and 4.4, respectively. Thus, sulpiride, which has been previously shown to be the most potent antagonist of the dopamine vascular receptors, is a very weak α-adrenergic or 5-HT antagonist.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalEuropean Journal of Pharmacology
Volume56
Issue number3
DOIs
StatePublished - Jun 15 1979
Externally publishedYes

Keywords

  • 5-HT antagonism
  • NE antagonism
  • Sulpiride

ASJC Scopus subject areas

  • Pharmacology

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