[11C]choline as a potential PET marker for imaging of breast cancer athymic mice

Qi Huang Zheng, K. Lee Stone, Bruce H. Mock, Kathy D. Miller, Xiangshu Fei, Xuan Liu, Ji Quan Wang, Barbara E. Glick-Wilson, George W. Sledge, Gary D. Hutchins

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

[11C]Choline has been evaluated as a potential positron emission tomography (PET) marker for imaging of breast cancer. The biodistribution of [11C]choline was determined at 45 min post iv injection in MCF-7's transfected with IL-1alpha implanted athymic mice and MDA-MB-435 implanted athymic mice. The results showed the uptake of [11C]choline in these tumors was high, 2.0% dose/g in MCF-7's transfected with IL-1alpha implanted mice and 1.8% dose/g in MDA-MB-435 implanted mice; the ratios of tumor/muscle (T/M) and tumor/blood (T/B) were 1.7 (T/M, MCF-7's), 2.1 (T/M, MDA-MB-435) and 6.9 (T/B, MCF-7's), 12.5 (T/B, MDA-MB-435), respectively; the tumor/muscle ratios are moderate, and the tumor/blood ratios are high. The micro-PET imaging of [11C]choline in both breast cancer athymic mice was acquired for 15 min from a MCF-7's transfected with IL-1alpha and/or MDA-MB-435 implanted mouse at 45 min post iv injection of 1 mCi of the tracer using a dedicated high resolution (<3 mm full-width at half-maximum) small FOV (field-of-view) PET imaging system, Indy-PET II scanner, developed in our laboratory, which showed the uptake of [11C]choline in MCF-7's transfected with IL-1alpha tumor or MDA-MB-435 tumor implanted in a nude athymic mouse. These results suggest that [11C]choline may be a potential PET breast cancer imaging agent.

Original languageEnglish (US)
Pages (from-to)803-807
Number of pages5
JournalNuclear Medicine and Biology
Volume29
Issue number8
DOIs
StatePublished - Nov 1 2002

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Keywords

  • [C]Choline
  • Breast cancer
  • Carbon-11
  • Positron emission tomography
  • Radiomarker
  • Solid-phase extraction

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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