1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy

J. Suhy, K. D. Laxer, A. A. Capizzano, P. Vermathen, G. B. Matson, N. M. Barbaro, M. W. Weiner

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

1H MRS imaging (MRSI) was performed on 15 patients with MRI-negative temporal lobe epilepsy (TLE) who underwent seizure surgery. The non-seizure-free patients (NSF) ipsilateral hippocampal N-acetylaspartate (NAA)/(Cr+Cho) z scores were lower than the contralateral scores (p = 0.04), and the NSF ipsilateral z scores were lower than the seizure-free patients' (SF) ipsilateral z scores (p = 0.0049). Similarly, NSF contralateral scores were lower than contralateral SF (p = 0.02). These findings suggest NAA predicts the surgical outcome in patients with TLE without evidence of mesial temporal sclerosis on MRI.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalNeurology
Volume58
Issue number5
DOIs
StatePublished - Mar 12 2002

ASJC Scopus subject areas

  • Clinical Neurology

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    Suhy, J., Laxer, K. D., Capizzano, A. A., Vermathen, P., Matson, G. B., Barbaro, N. M., & Weiner, M. W. (2002). 1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy. Neurology, 58(5), 821-823. https://doi.org/10.1212/WNL.58.5.821